1] Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA. [2].
Nat Chem Biol. 2013 Oct;9(10):594-8. doi: 10.1038/nchembio.1339.
Genetic code expansion for synthesis of proteins containing noncanonical amino acids is a rapidly growing field in synthetic biology. Creating optimal orthogonal translation systems will require re-engineering central components of the protein synthesis machinery on the basis of a solid mechanistic biochemical understanding of the synthetic process.
遗传密码扩展用于合成含有非天然氨基酸的蛋白质是合成生物学中一个快速发展的领域。要创建最佳的正交翻译系统，需要在对合成过程的坚实的机制生化理解的基础上，对蛋白质合成机制的核心组件进行工程改造。
