Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; Institute of Health Sciences, Free University, Amsterdam, The Netherlands.
Cancer. 2011 Jun 1;117(11):2398-407. doi: 10.1002/cncr.25772. Epub 2010 Dec 17.
The metabolic syndrome (MetS) has been related to an increased risk of colorectal cancer, but the modest size of previous studies precluded detailed characterization of the role of individual MetS factors and their interaction on risk.
In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI), blood pressure, and blood levels of glucose, cholesterol, and triglycerides were available for 578,700 men and women. The mean age of participants at baseline was 44 years, and the mean follow-up was 12 years. Relative risks (RR) of colorectal cancer per 1 standard deviation increment in Z score of factors and for a combined MetS score, were calculated from Cox regression models, including adjustment for potential confounders.
During follow-up, 2834 men and 1861 women were diagnosed with colorectal cancer. The RR of colorectal cancer for the MetS score was 1.25 (95% confidence interval [CI], 1.18-1.32) in men, and 1.14 (95% CI, 1.06-1.22) in women. Significant associations also were observed in men for BMI (RR, 1.07; 95% CI, 1.02-1.13), blood pressure (RR, 1.10; 95% CI, 1.02-1.18), and triglycerides (RR, 1.17; 95% CI, 1.06-1.28) and, in women, for BMI (RR, 1.08; 95% CI, 1.01-1.15). There was no significant positive interaction between the metabolic factors on risk.
The combination of metabolic factors and some separate factors was related to an increased risk of colorectal cancer, but there was no interaction between metabolic factors.
代谢综合征（MetS）与结直肠癌风险增加相关，但先前研究的规模较小，无法详细描述单个 MetS 因素及其相互作用对风险的作用。
在代谢综合征和癌症项目（Me-Can）中，有 578700 名男性和女性的体重指数（BMI）、血压以及血糖、胆固醇和甘油三酯的血液水平数据可用。参与者的基线年龄平均为 44 岁，平均随访时间为 12 年。使用 Cox 回归模型，包括对潜在混杂因素的调整，计算出每个因素 Z 分数的标准偏差增量和综合 MetS 评分的结直肠癌风险相对风险（RR）。
在随访期间，2834 名男性和 1861 名女性被诊断患有结直肠癌。男性的 MetS 评分的结直肠癌 RR 为 1.25（95%置信区间 [CI]，1.18-1.32），女性为 1.14（95% CI，1.06-1.22）。在男性中，BMI（RR，1.07；95% CI，1.02-1.13）、血压（RR，1.10；95% CI，1.02-1.18）和甘油三酯（RR，1.17；95% CI，1.06-1.28）也存在显著关联，在女性中，BMI（RR，1.08；95% CI，1.01-1.15）也存在显著关联。代谢因素之间的风险没有显著的正交互作用。
代谢因素的组合和一些单独的因素与结直肠癌风险增加有关，但代谢因素之间没有相互作用。
