Mogarekar Mukund Ramchandra, Rojekar Mohit Vijay
Department of Biochemistry, SRTR Govt Medical College, Ambajogai, 431517, Maharashtra, India.
Indian J Pediatr. 2014 Aug;81(8):760-1. doi: 10.1007/s12098-013-1228-z. Epub 2013 Sep 19.
To evaluate arylesterase and lactonase activity of paraoxonase (PON)1 in cord blood of neonates in relation to their birth weight. The authors hypothesized that cord blood PON1 arylesterase and lactonase activities will be compromised in neonates having low birth weight.
Eighty neonates born in authors' hospital, irrespective of mode of delivery were included. Forty children with low birth weight were included in case group and 40 with normal birth weight were included as controls. PON1 arylesterase and lactonase activities were measured.
Serum arylesterase activity decreased significantly in low birth weight babies (p < 0.05). Linear regression analysis (R = 0.728) indicated significant correlation between arylesterase and birth weight. Serum lactonase activity was also reduced in low birth weight babies. Its linear regression analysis (R = 0.727) indicated significant correlation between lactonase and birth weight.
PON 1 activity is significantly reduced among low birth weight babies in comparison to normal weight babies.
评估新生儿脐带血中对氧磷酶（PON）1的芳基酯酶和内酯酶活性与其出生体重的关系。作者推测，低出生体重新生儿的脐带血PON1芳基酯酶和内酯酶活性会受到损害。
纳入作者所在医院出生的80例新生儿，无论分娩方式如何。病例组纳入40例低出生体重儿，40例出生体重正常的儿童作为对照组。测量PON1芳基酯酶和内酯酶活性。
低出生体重儿血清芳基酯酶活性显著降低（p < 0.05）。线性回归分析（R = 0.728）表明芳基酯酶与出生体重之间存在显著相关性。低出生体重儿血清内酯酶活性也降低。其线性回归分析（R = 0.727）表明内酯酶与出生体重之间存在显著相关性。
与正常体重儿相比，低出生体重儿的PON 1活性显著降低。
