Aneja Jitender, Basu Debasish, Mattoo Surendra Kumar, Kohli Krishan Kumar
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Psychol Med. 2013 Apr;35(2):190-6. doi: 10.4103/0253-7176.116253.
In the context to mental illness metabolic syndrome (MS) has gained significant attention in the last decade. The present research aimed to study the prevalence of MS and its correlates among the alcohol-dependent men at a deaddiction center in Northern India.
A cross-sectional analysis was done for consecutive male subjects who met the diagnosis of alcohol-dependence syndrome currently using alcohol according to the International Clinical Diagnostic criteria- tenth revision mental and behavioral disorder- Clinical description and diagnostic guidelines criteria (ICD-10). The subjects were evaluated for alcohol consumption and the components of MS as per the International Diabetic Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel-III (NCEP ATP-III).
A total of 200 male subjects were studied: 100 subjects meeting ICD-10 criteria for alcohol dependence currently using alcohol; 50 each of genetically related controls and nongenetically related healthy controls. As per the IDF (with ethnicity specific modifications for waist circumference) and NCEP ATP- III definitions, respectively, MS was found to be less prevalent in alcohol-dependent subjects (27% and 18%) in comparison the healthy controls (30% and 20%).
Findings of the study suggest that irrespective of the amount the current alcohol intake is associated with a lower prevalence of MS and a favorable effect on serum high density lipoproteins and waist circumference. However, the cross-sectional nature of our study does not allow any definitive causal inference.
在精神疾病的背景下，代谢综合征（MS）在过去十年中受到了广泛关注。本研究旨在调查印度北部一家戒毒中心酒精依赖男性中MS的患病率及其相关因素。
对符合国际临床诊断标准第十版精神与行为障碍——临床描述与诊断指南标准（ICD - 10）中酒精依赖综合征诊断且目前正在饮酒的连续男性受试者进行横断面分析。根据国际糖尿病联盟（IDF）和美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP ATP - III）对受试者的饮酒情况和MS的各项组分进行评估。
共研究了200名男性受试者：100名符合ICD - 10酒精依赖标准且目前正在饮酒的受试者；50名遗传相关对照者和50名非遗传相关健康对照者。根据IDF（对腰围进行种族特异性修正）和NCEP ATP - III的定义，与健康对照者（分别为30%和20%）相比，酒精依赖受试者中MS的患病率较低（分别为27%和18%）。
研究结果表明，无论当前酒精摄入量多少，均与较低的MS患病率相关，且对血清高密度脂蛋白和腰围有有益影响。然而，本研究的横断面性质不允许进行任何确定性的因果推断。
