长期使用呋喃妥因所致的可逆性间质性肺疾病：益处是否大于风险？

Reversible interstitial lung disease with prolonged use of nitrofurantoin: Do the benefits outweigh the risks?

作者信息

Singh Akashdeep, Singh Parminder, Sidhu U S

机构信息

Department of Pulmonary and Critical Care Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

出版信息

Lung India. 2013 Jul;30(3):212-4. doi: 10.4103/0970-2113.116271.

DOI:10.4103/0970-2113.116271

PMID:24049258

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3775203/

Abstract

We describe the case summary of a 70-year-old man diagnosed with interstitial lung disease due to prolonged nitrofurantoin therapy. Despite honeycombing confirmed by computed tomography of the thorax, symptoms and radiographic findings disappeared within 1 month after withdrawal of nitrofurantoin. The case highlights the fact that nitrofurantoin-induced lung disease may run a benign course and respond favorably despite radiographic evidence of established lung fibrosis (honey combing).

摘要

我们描述了一名70岁男性因长期服用呋喃妥因而被诊断为间质性肺病的病例摘要。尽管胸部计算机断层扫描证实存在蜂窝状改变，但在停用呋喃妥因后1个月内，症状和影像学表现均消失。该病例突出了这样一个事实，即呋喃妥因诱发的肺病可能呈良性病程，尽管影像学显示已存在肺纤维化（蜂窝状改变），但仍可能有良好的反应。