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地衣芽孢杆菌中β-内酰胺酶产生的信号转导蛋白BlaR被鉴定为一种青霉素结合蛋白，与鼠伤寒沙门氏菌的OXA-2β-内酰胺酶（D类）具有高度同源性。

Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium.

作者信息

Zhu Y F, Curran I H, Joris B, Ghuysen J M, Lampen J O

机构信息

Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855-0759.

出版信息

J Bacteriol. 1990 Feb;172(2):1137-41. doi: 10.1128/jb.172.2.1137-1141.1990.

DOI:10.1128/jb.172.2.1137-1141.1990
PMID:2404938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC208548/
Abstract

The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A beta-lactamase. The protein product, BlaR, has a hydrophilic carboxy region that binds beta-lactams and shows high sequence homology to the class D beta-lactamases, particularly the OXA-2 beta-lactamase of Salmonella typhimurium. The BlaR-beta-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.

摘要

地衣芽孢杆菌的blaR基因编码A类β-内酰胺酶诱导的信号转导子。其蛋白质产物BlaR具有一个结合β-内酰胺的亲水性羧基区域，并且与D类β-内酰胺酶具有高度的序列同源性，尤其是鼠伤寒沙门氏菌的OXA-2β-内酰胺酶。BlaR-β-内酰胺复合物是稳定的，可能为该酶的持续产生提供所需的持续刺激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c9/208548/dc719a4138ee/jbacter01044-0637-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c9/208548/dc719a4138ee/jbacter01044-0637-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c9/208548/dc719a4138ee/jbacter01044-0637-a.jpg

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1
Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium.地衣芽孢杆菌中β-内酰胺酶产生的信号转导蛋白BlaR被鉴定为一种青霉素结合蛋白，与鼠伤寒沙门氏菌的OXA-2β-内酰胺酶（D类）具有高度同源性。
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本文引用的文献

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Penicillin-binding proteins in bacteria.细菌中的青霉素结合蛋白
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Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries.核酸序列中的模式识别。I. 寻找局部同源性和对称性的通用方法。
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ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.
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Constructing and deconstructing the bacterial cell wall.构建与解构细菌细胞壁。
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Regulation and Anaerobic Function of the β-Lactamase.β-内酰胺酶的调节与厌氧功能。
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Structural phylogeny by profile extraction and multiple superimposition using electrostatic congruence as a discriminator.通过轮廓提取和使用静电一致性作为判别器的多重叠加进行结构系统发育分析。
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Site-saturation mutagenesis of position V117 in OXA-1 β-lactamase: effect of side chain polarity on enzyme carboxylation and substrate turnover.OXA-1β-内酰胺酶位置 V117 的定点饱和突变：侧链极性对酶羧化和底物周转的影响。
Biochemistry. 2012 Apr 10;51(14):3143-50. doi: 10.1021/bi201896k. Epub 2012 Mar 28.
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Penicillin sulfone inhibitors of class D beta-lactamases.D 类β-内酰胺酶的青霉素砜抑制剂。
Antimicrob Agents Chemother. 2010 Apr;54(4):1414-24. doi: 10.1128/AAC.00743-09. Epub 2010 Jan 19.
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Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme.OXA-1β-内酰胺酶活性位点的羧基赖氨酸（K70）发生突变会导致一种脱酰化缺陷型酶。
Biochemistry. 2009 Jul 7;48(26):6136-45. doi: 10.1021/bi900448u.
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Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.耐甲氧西林金黄色葡萄球菌和表皮葡萄球菌mecI基因及mecA启动子/操纵子区域突变多样性分析
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大肠杆菌K-12的AmpC头孢菌素酶与青霉素酶型β-内酰胺酶有着不同的进化起源。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4897-901. doi: 10.1073/pnas.78.8.4897.
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Penicillinase from Bacillus licheniformis: nucleotide sequence of the gene and implications for the biosynthesis of a secretory protein in a Gram-positive bacterium.地衣芽孢杆菌青霉素酶：基因的核苷酸序列及其对革兰氏阳性菌中分泌蛋白生物合成的影响。
Nucleic Acids Res. 1981 Jun 11;9(11):2577-88. doi: 10.1093/nar/9.11.2577.
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The structure of beta-lactamases.β-内酰胺酶的结构
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The genetics of Bacillus licheniformis penicillinase: a preliminary analysis from studies on mutation and inter-strain and intra-strain transformations.地衣芽孢杆菌青霉素酶的遗传学：基于突变、菌株间及菌株内转化研究的初步分析
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Rapid fixed-time assay for penicillinase.青霉素酶快速定时测定法
J Bacteriol. 1968 Apr;95(4):1493-4. doi: 10.1128/jb.95.4.1493-1494.1968.
8
Analysis by transformation of the penicillinase system in Bacillus licheniformis.地衣芽孢杆菌青霉素酶系统转化分析。
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9
Sequence of the OXA2 beta-lactamase: comparison with other penicillin-reactive enzymes.OXA2β-内酰胺酶的序列：与其他青霉素反应性酶的比较。
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10
The crystal structure of the beta-lactamase of Streptomyces albus G at 0.3 nm resolution.白色链霉菌G的β-内酰胺酶在0.3纳米分辨率下的晶体结构。
Biochem J. 1987 Aug 1;245(3):911-3. doi: 10.1042/bj2450911.