Ganeshpurkar Aditya, Diwedi Varsha, Bhardwaj Yash
Assistant Professor, Drug Discovery Laboratory, Department of Pharmacology, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
Ayu. 2013 Jan;34(1):109-12. doi: 10.4103/0974-8520.115446.
Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was designed to investigate the inhibitory potential of ethyl acetate and water extract of T. foenum-graecum on enzymes α-amylase and α-glucosidase. Different concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and α-glucosidase. A dose dependent inhibitory effect on enzymes was observed. The current study, for the first time, revealed α-amylase and α-glucosidase inhibitory potential of T. foenum-graecum and the study could be helpful to isolate and characterize compounds responsible for it.
胡芦巴是食品和医药领域广泛使用的草药之一。人们对该植物的种子进行了抗糖尿病潜力的研究；然而，尚未有人探索其叶子对碳水化合物代谢酶即α-淀粉酶和α-葡萄糖苷酶的影响。本研究旨在探究胡芦巴乙酸乙酯提取物和水提取物对α-淀粉酶和α-葡萄糖苷酶的抑制潜力。使用不同浓度的提取物来研究对α-淀粉酶和α-葡萄糖苷酶活性的抑制作用。观察到提取物对这些酶具有剂量依赖性抑制作用。本研究首次揭示了胡芦巴对α-淀粉酶和α-葡萄糖苷酶的抑制潜力，该研究有助于分离和鉴定负责此作用的化合物。
