Diabetes Interest Group, The Centre for Health and Life Sciences Research, London Metropolitan University, London N7 8DB, UK.
Int J Mol Sci. 2024 Jun 26;25(13):6987. doi: 10.3390/ijms25136987.
The number of people diagnosed with type 2 diabetes is on the increase worldwide. Of growing concern, the prevalence of type 2 diabetes in children and youths is increasing rapidly and mirrors the increasing burden of childhood obesity. There are many risk factors associated with the condition; some are due to lifestyle, but many are beyond our control, such as genetics. There is an urgent need to develop better therapeutics for the prevention and management of this complex condition since current medications often cause unwanted side effects, and poorly managed diabetes can result in the onset of related comorbidities. Naturally derived compounds have gained momentum for preventing and managing several complex conditions, including type 2 diabetes. Here, we provide an update on the benefits and limitations of fenugreek and its components as a therapeutic for type 2 diabetes, including its bioavailability and interaction with the microbiome.
全世界被诊断患有 2 型糖尿病的人数在不断增加。令人担忧的是，儿童和青少年 2 型糖尿病的患病率正在迅速上升，与儿童肥胖症的负担增加相吻合。这种疾病有许多相关的风险因素；有些是由于生活方式造成的，但也有许多是我们无法控制的，如遗传因素。由于目前的药物经常会引起不良反应，而且糖尿病管理不善会导致相关并发症的发生，因此迫切需要开发更好的治疗方法来预防和管理这种复杂的疾病。天然化合物在预防和治疗多种复杂疾病方面已经取得了进展，包括 2 型糖尿病。在这里，我们提供了关于葫芦巴及其成分作为 2 型糖尿病治疗药物的益处和局限性的最新信息，包括其生物利用度以及与微生物组的相互作用。
