Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA.
Curr Opin Immunol. 2013 Oct;25(5):598-605. doi: 10.1016/j.coi.2013.08.005. Epub 2013 Sep 18.
Systemic autoimmune diseases result from interactions between genes and environmental triggers that lead to dysregulation of both innate and adaptive immunity. Systems biology approaches enable the global characterization of complex systems at the DNA, RNA and protein levels. Recent technological breakthroughs such as deep sequencing or high-throughput proteomics are revealing novel inflammatory pathways involved in autoimmunity. Herein, we review recent developments, challenges and promising avenues in the use of systems approaches to understand human systemic autoimmune and autoinflammatory diseases.
系统性自身免疫性疾病是由基因与环境触发因素相互作用引起的，导致先天免疫和适应性免疫失调。系统生物学方法能够在 DNA、RNA 和蛋白质水平上对复杂系统进行全面描述。最近的技术突破，如深度测序或高通量蛋白质组学，揭示了自身免疫中涉及的新的炎症途径。本文综述了应用系统方法理解人类系统性自身免疫性和自身炎症性疾病的最新进展、挑战和有前途的途径。
