Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, Wuhan, 430070, People's Republic of China.
Mol Biol Rep. 2013 Nov;40(11):6075-9. doi: 10.1007/s11033-013-2717-x. Epub 2013 Sep 22.
Ten single nucleotide polymorphisms were used for genotyping of 176 Tongshan Black-boned goats, which are Chinese indigenous goat colony for meat production. The average individual heterozygosity was 0.292. To assess the correlations between individual heterozygosity and growth in Tongshan Black-boned goat individuals, and the potential of using individual heterozygosity as an indicator of growth, the data of growth traits, including body weight, height at withers, body length, chest girth and cannon circumference, were collected. Significant correlations were observed between individual heterozygosity and body weight, height at withers, body length, heart girth, cannon circumference (P < 0.05). All the significant regression showed positive slope with R square values ranged from 0.0251 to 0.0368. These data suggests that individual heterozygosity is positively correlated with growth traits in Tongshan Black-boned goat individuals and associative overdominance may affect Tongshan Black-boned goat growth significantly. Therefore it is possible to use individual heterozygosity as an indicator of growth. Our results also provide a strong support to the overdominance hypothesis.
选用 10 个单核苷酸多态性(SNP)位点对 176 只通山黑山羊进行基因分型，该羊种是中国本土的肉用山羊品种。平均个体杂合度为 0.292。为了评估通山黑山羊个体的个体杂合度与生长之间的相关性，以及个体杂合度作为生长指标的潜力，收集了生长性状的数据，包括体重、体高、体长、胸围和管围。个体杂合度与体重、体高、体长、胸围和管围均呈显著正相关(P < 0.05)。所有显著的回归方程斜率均为正，R 平方值范围为 0.0251 至 0.0368。这些数据表明，个体杂合度与通山黑山羊个体的生长性状呈正相关，关联超显性可能显著影响通山黑山羊的生长。因此，个体杂合度可以作为生长指标。我们的研究结果也为超显性假说提供了有力支持。
