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肥胖孕妇治疗(TOP)研究:一项随机对照试验,评估了通过计步器评估的体力活动干预与饮食干预相结合或不结合对肥胖孕妇的影响。

The Treatment of Obese Pregnant Women (TOP) study: a randomized controlled trial of the effect of physical activity intervention assessed by pedometer with or without dietary intervention in obese pregnant women.

机构信息

Department of Obstetrics and Gynecology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.

Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.

出版信息

Am J Obstet Gynecol. 2014 Feb;210(2):134.e1-9. doi: 10.1016/j.ajog.2013.09.029. Epub 2013 Sep 20.

DOI:10.1016/j.ajog.2013.09.029
PMID:24060449
Abstract

OBJECTIVE

The objective of the study was to assess physical activity intervention assessed by a pedometer with or without dietary intervention on gestational weight gain (GWG) in obese pregnant women by comparing with a control group.

STUDY DESIGN

This study was a randomized controlled trial of 425 obese pregnant women comparing 3 groups: (1) PA plus D, physical activity and dietary intervention (n = 142); (2) PA, physical activity intervention (n = 142); and (3) C, a control group receiving standard care (n = 141). All participants routinely in gestational weeks 11-14 had an initial dietary counseling session and were advised to limit GWG to less than 5 kg. Physical activity intervention included encouragement to increase physical activity, aiming at a daily step count of 11,000, monitored by pedometer assessment on 7 consecutive days every 4 weeks. Dietary intervention included follow-up on a hypocaloric Mediterranean-style diet. Instruction was given by a dietician every 2 weeks. The primary outcome measure was GWG, and the secondary outcome measures were complications of pregnancy and delivery and neonatal outcome.

RESULTS

The study was completed by 389 patients (92%). Median values of GWG (ranges) were lower in each of the intervention groups (PA plus D, 8.6 [-9.6 to 34.1] kg, and group PA, 9.4 [-3.4 to 28.2] kg) compared with the control group (10.9 [-4.4 to 28.7] kg [PA+D vs C]; P = .01; PA vs C; P = .042). No significant difference was found between the 2 intervention groups. In a multivariate analysis, physical activity intervention decreased GWG by a mean of 1.38 kg (P = .040). The Institute of Medicine's recommendations for GWG were more frequently followed in the intervention groups.

CONCLUSION

Physical activity intervention assessed by pedometer with or without dietary follow-up reduced GWG compared with controls in obese pregnant women.

摘要

目的

本研究旨在评估通过计步器评估的体力活动干预措施,以及是否结合饮食干预,对肥胖孕妇的妊娠体重增加(GWG)的影响,与对照组进行比较。

研究设计

这是一项比较 3 组肥胖孕妇的随机对照试验:(1)PA+D 组,体力活动和饮食干预(n=142);(2)PA 组,体力活动干预(n=142);(3)C 组,对照组,接受标准护理(n=141)。所有参与者在妊娠 11-14 周时常规进行初始饮食咨询,并建议将 GWG 限制在 5 公斤以内。体力活动干预包括鼓励增加体力活动,目标是每天计步 11000 步,每 4 周通过计步器评估连续 7 天监测。饮食干预包括随访低热量的地中海式饮食。营养师每两周进行一次指导。主要结局测量指标是 GWG,次要结局测量指标是妊娠和分娩并发症以及新生儿结局。

结果

共有 389 名患者(92%)完成了研究。每个干预组(PA+D 组,8.6[9.6 至 34.1]公斤;PA 组,9.4[3.4 至 28.2]公斤)的 GWG 中位数(范围)均低于对照组(10.9[4.4 至 28.7]公斤[PA+D 与 C 相比,P=0.01;PA 与 C 相比,P=0.042)。两个干预组之间没有发现显著差异。在多变量分析中,体力活动干预使 GWG 平均减少 1.38 公斤(P=0.040)。在干预组中,《美国医学研究所》(Institute of Medicine)对 GWG 的建议更频繁地得到遵循。

结论

与对照组相比,通过计步器评估的体力活动干预措施,以及是否结合饮食随访,可减少肥胖孕妇的 GWG。

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