聚二甲基硅氧烷稳定的低污染等离子体聚合物涂层。
Stable low-fouling plasma polymer coatings on polydimethylsiloxane.
机构信息
Department of Engineering Materials, Kroto Research Institute, University of Sheffield, Sheffield Biotactical Engineering Group, IRIS, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn 3122, Australia.
出版信息
Biomicrofluidics. 2012 Sep 24;6(3):36504. doi: 10.1063/1.4754600. eCollection 2012.
Abstract
Polydimethylsiloxane (DMS) is a popular material for microfluidics, but it is hydrophobic and is prone to non-specific protein adsorption. In this study, we explore methods for producing stable, protein resistant, tetraglyme plasma polymer coatings on PDMS by combining extended baking processes with multiple plasma polymer coating steps. We demonstrate that by using this approach, it is possible to produce a plasma polymer coatings that resist protein adsorption (<10 ng/cm(2)) and are stable to storage over at least 100 days. This methodology can translate to any plasma polymer system, enabling the introduction of a wide range of surface functionalities on PDMS surfaces.
摘要
聚二甲基硅氧烷（DMS）是微流控领域常用的材料，但它具有疏水性，容易发生非特异性蛋白质吸附。在这项研究中，我们探索了通过结合延长烘焙过程和多次等离子体聚合涂层步骤来在 PDMS 上生成稳定、抗蛋白质吸附的四甘醇等离子体聚合物涂层的方法。我们证明，通过采用这种方法，可以制备出抗蛋白质吸附（<10ng/cm(2)）且在至少 100 天的储存时间内稳定的等离子体聚合物涂层。这种方法可以转化为任何等离子体聚合物体系，从而在 PDMS 表面引入广泛的表面功能。
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