假性剥脱综合征患者氧化应激增加。
Increased oxidative stress in patients with pseudoexfoliation syndrome.
机构信息
Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
出版信息
Ophthalmic Res. 2010;43(4):169-72. doi: 10.1159/000272019. Epub 2009 Dec 31.
PURPOSE
The objective of this study was to investigate the antioxidant/oxidant status of serum in patients with pseudoexfoliation syndrome (PEX).
METHODS
Forty-seven patients with PEX and 32 healthy controls were included in the study. Serum total antioxidant capacity (TAC) and total oxidant status (TOS) levels were determined by using a novel automated method.
RESULTS
A significant increase in serum TOS (p < 0.001) and a significant decrease in serum TAC (p < 0.0001) were observed in PEX patients compared to control subjects.
CONCLUSION
TAC decreases while the oxidative stress increases in PEX.
目的
本研究旨在探讨原发性开角型青光眼（POAG）患者血清中的抗氧化/氧化状态。
方法
本研究纳入了 47 名 POAG 患者和 32 名健康对照者。采用新型自动化方法测定血清总抗氧化能力（TAC）和总氧化状态（TOS）水平。
结果
与对照组相比，POAG 患者血清 TOS 显著升高（p<0.001），TAC 显著降低（p<0.0001）。
结论
POAG 患者的 TAC 降低，氧化应激增加。
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