Healey M A, Brown R, Fleiszer D
Surgical Intensive Care and Trauma Unit, McGill University, Montreal General Hospital, Ontario, Canada.
J Trauma. 1990 Feb;30(2):137-46.
The diagnosis of blunt cardiac injury in traumatized patients is problematic and the implications of such a diagnosis are not clear. Although cardiac selective creatine kinase (CK-MB) assays and electrocardiograms (EKG) are the most widely available laboratory investigations, they often correlate poorly with diagnoses made on clinical grounds, or by other laboratory methods. We therefore retrospectively studied the Montreal General Hospital experience with 342 consecutive blunt trauma patients admitted to our surgical intensive care/trauma unit. Using clinical criteria, cardiac injury was diagnosed in 44 patients (13%). Twenty-seven of these patients (61%) developed arrythmias or cardiogenic hypotension, half of which required treatment. Heart injuries contributed to six of the 12 deaths in this group. Many of the patients maintained normal CK-MB levels and/or had normal admission EKG's despite the clinical diagnosis of cardiac injury. However, using our criteria for CK-MB positivity, there was a strong correlation between CK-MB elevation and the development of cardiac complications, and very high CK-MB levels (greater than 200 mu/L) were associated with a 100% incidence of such complications. Focusing on patients who developed cardiac complications serious enough to require treatment, we found combined CK-MB/EKG positivity in all cases (100% sensitivity). This method also provided a negative predictive value of 100%. We conclude that although blunt cardiac injury is an important source of morbidity and mortality its 'diagnosis' is not the issue. Rather, it is more important to recognize which of these clinically identified 'high-risk' patients will actually develop cardiac complications. We feel our approach will enable clinicians to do this.
创伤患者钝性心脏损伤的诊断存在问题,且这种诊断的意义尚不明确。尽管心脏特异性肌酸激酶(CK-MB)检测和心电图(EKG)是最常用的实验室检查,但它们与基于临床或其他实验室方法做出的诊断往往相关性较差。因此,我们回顾性研究了蒙特利尔总医院收治到外科重症监护/创伤病房连续342例钝性创伤患者的情况。根据临床标准,44例患者(13%)被诊断为心脏损伤。其中27例患者(61%)出现心律失常或心源性低血压,半数需要治疗。心脏损伤导致该组12例死亡中的6例。尽管临床诊断为心脏损伤,但许多患者的CK-MB水平保持正常和/或入院时心电图正常。然而,根据我们的CK-MB阳性标准,CK-MB升高与心脏并发症的发生之间存在很强的相关性,且CK-MB水平非常高(大于200μ/L)与这些并发症的发生率100%相关。关注那些出现严重到需要治疗的心脏并发症的患者,我们发现所有病例(敏感性100%)的CK-MB/EKG联合阳性。该方法还提供了阴性预测值100%。我们得出结论,尽管钝性心脏损伤是发病率和死亡率的重要来源,但其“诊断”并非问题所在。更重要的是识别出这些临床确定的“高危”患者中哪些实际上会发生心脏并发症。我们认为我们的方法将使临床医生能够做到这一点。