Fattouch Khalil, Castrovinci Sebastiano, Murana Giacomo, Nasso Giuseppe, Guccione Francesco, Dioguardi Pietro, Salardino Massimo, Bianco Giuseppe, Speziale Giuseppe
Department of Cardiovascular Surgery, GVM Care and Research, Maria Eleonora Hospital, Palermo, Italy.
Interact Cardiovasc Thorac Surg. 2014 Jan;18(1):49-54; discussion 54-5. doi: 10.1093/icvts/ivt410. Epub 2013 Sep 24.
The functional aortic valve annulus (FAVA) is a complex unit with proximal (aorto-ventricular junction) and distal (sinotubular junction) components. The aim of our study was to evaluate the impact of the total FAVA remodelling, using a prosthetic ring, on mid-term clinical and echocardiographic results after aortic valve repair.
Since February 2003, 250 patients with tricuspid aortic valve insufficiency (AI) underwent aortic valve repair. FAVA dilatation was treated by prosthetic ring in 52 patients, by isolated subcommissural plasty in 62, by subcommissural plasty plus ascending aortic replacement in 57 and by David's reimplantation procedure in 79. Survival rate and freedom from recurrent AI greater than or equal to moderate were evaluated by Kaplan-Meier.
Overall late survival was 90.4%. Late cardiac-related deaths occurred in 15 patients. At follow-up, 36 (16%) patients had recurrent AI greater than or equal to moderate because of cusp reprolapse and/or FAVA redilatation. Freedom from recurrent AI was significantly higher for patients who underwent David's procedure or FAVA remodelling by prosthetic ring than those who underwent isolated subcommissural plasty (P < 0.01) or subcommissural plasty plus ascending aortic replacement (P = 0.02). There was no statistical difference between David's procedure and prosthetic ring annuloplasty (P = 0.26).
FAVA remodelling using a prosthetic ring is a safe procedure in aortic valve repair surgery thanks to long-term annulus stabilization and it is a pliable alternative to David's procedure in selected patients. This technique may be used in all patients with slight root dilatation to avoid aggressive root reimplantation. We also recommended total FAVA annuloplasty in all patients who underwent aortic valve repair to improve long-term repair results.
功能性主动脉瓣环(FAVA)是一个复杂的结构,包括近端(主动脉-心室连接)和远端(窦管连接)部分。我们研究的目的是评估使用人工瓣环进行FAVA整体重塑对主动脉瓣修复术后中期临床和超声心动图结果的影响。
自2003年2月以来,250例三尖瓣主动脉瓣关闭不全(AI)患者接受了主动脉瓣修复术。52例患者采用人工瓣环治疗FAVA扩张,62例采用单纯交界下成形术,57例采用交界下成形术加升主动脉置换术,79例采用大卫氏再植入术。采用Kaplan-Meier法评估生存率和无中度及以上复发性AI的情况。
总体晚期生存率为90.4%。15例患者发生晚期心脏相关死亡。随访时,36例(16%)患者因瓣叶再脱垂和/或FAVA再扩张出现中度及以上复发性AI。接受大卫氏手术或人工瓣环FAVA重塑的患者无复发性AI的比例显著高于接受单纯交界下成形术(P<0.01)或交界下成形术加升主动脉置换术(P=0.02)的患者。大卫氏手术和人工瓣环成形术之间无统计学差异(P=0.26)。
在主动脉瓣修复手术中,使用人工瓣环进行FAVA重塑是一种安全的手术方法,因为它能实现长期瓣环稳定,并且在特定患者中是大卫氏手术的灵活替代方案。该技术可用于所有轻度根部扩张的患者,以避免进行激进的根部再植入。我们还建议对所有接受主动脉瓣修复的患者进行FAVA全瓣环成形术,以改善长期修复效果。