Licis Amy K, Vallorani Alicia, Gao Feng, Chen Cynthia, Lenox Jason, Yamada Kelvin A, Duntley Stephen P, Gutmann David H
1Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
J Child Neurol. 2013 Nov;28(11):1400-1405. doi: 10.1177/0883073813500849. Epub 2013 Sep 23.
Children with neurodevelopmental disorders are at increased risk for sleep issues, which affect quality of life, cognitive function, and behavior. To determine the prevalence of sleep problems in children with the common neurodevelopmental disorder neurofibromatosis type 1, a cross-sectional study was performed on 129 affected subjects and 89 unaffected siblings, age 2 to 17 years, using the Sleep Disturbance Scale for Children questionnaire. Children with neurofibromatosis type 1 were significantly more likely to have disturbances in initiating and maintaining sleep, arousal, sleep-wake transition, and hyperhidrosis, but not problems with abnormal sleep breathing, or excessive somnolence. Although the overall sleep scores were higher in children with neurofibromatosis type 1, this was not related to a coexisting attention deficit disorder, cognitive impairment, or stimulant medication use. Collectively, these results demonstrate that children with neurofibromatosis type 1 are more likely to have sleep disturbances, and support the use of appropriate interventions for this at-risk population.
患有神经发育障碍的儿童出现睡眠问题的风险增加，这些问题会影响生活质量、认知功能和行为。为了确定常见神经发育障碍1型神经纤维瘤病患儿睡眠问题的患病率，对129名患病受试者和89名未患病的兄弟姐妹（年龄在2至17岁之间）进行了一项横断面研究，使用儿童睡眠障碍量表问卷。1型神经纤维瘤病患儿在入睡和维持睡眠、觉醒、睡眠-觉醒转换及多汗方面出现障碍的可能性显著更高，但在睡眠呼吸异常或过度嗜睡方面没有问题。尽管1型神经纤维瘤病患儿的总体睡眠评分较高，但这与同时存在的注意力缺陷障碍、认知障碍或使用兴奋剂药物无关。总体而言，这些结果表明，1型神经纤维瘤病患儿更有可能出现睡眠障碍，并支持对这一高危人群采取适当的干预措施。
