Martinez-Martinez Pilar, Molenaar Peter C, Losen Mario, Stevens Jo, Baets Marc H De, Szoke Andrei, Honnorat Jerome, Tamouza Ryad, Leboyer Marion, Os Jim Van, Rutten Bart P F
Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University Maastricht, Netherlands.
Front Genet. 2013 Sep 20;4:181. doi: 10.3389/fgene.2013.00181.
Changes of voltage-gated ion channels and ligand-gated receptor channels caused by mutation or autoimmune attack are the cause of so-called channelopathies in the central and peripheral nervous system. We present the pathophysiology of channelopathies of the neuromuscular junction in terms of loss-of-function and gain-of-function principles. Autoantibodies generally have reduced access to the central nervous system, but in some cases this is enough to cause disease. A review is provided of recent findings implicating autoantibodies against ligand-activated receptor channels and potassium channels in psychiatric and neurological disorders, including schizophrenia and limbic encephalitis. The emergence of channelopathy-related neuropsychiatric disorders has implications for research and practice.
由突变或自身免疫攻击引起的电压门控离子通道和配体门控受体通道的变化是中枢和周围神经系统中所谓通道病的病因。我们从功能丧失和功能获得原理的角度阐述神经肌肉接头通道病的病理生理学。自身抗体通常难以进入中枢神经系统，但在某些情况下，这足以引发疾病。本文综述了近期的研究发现，这些发现表明针对配体激活受体通道和钾通道的自身抗体与精神和神经疾病有关，包括精神分裂症和边缘性脑炎。与通道病相关的神经精神疾病的出现对研究和实践具有重要意义。
