Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650051, Yunnan, People's Republic of China.
Anticancer Agents Med Chem. 2014 Feb;14(2):280-9. doi: 10.2174/18715206113136660337.
Re-programming of metabolic pathways is a hallmark of pathological changes in cancer cells. The expression of certain genes that directly control the rate of key metabolic pathways including glycolysis, lipogenesis and nucleotide synthesis is dysregulated for the adaptation and progression of tumor cells to become more aggressive phenotypes. The pentose phosphate pathway controlled by glucose- 6-phosphate dehydrogenase (G6PD) has been appreciated largely to its role as a provider of reducing power and ribose phosphate to the cell for maintenance of redox balance and biosynthesis of nucleotides and lipids. Recently, G6PD has been revealed to be involved in apoptosis, angiogenesis, and the efficacy to anti-cancer therapy, making it as a promising target in cancer therapy. This review summarizes the information about the latest progress relating the activity of the G6PD to cell proliferation, angiogenesis, and resistance to therapy in cancer cells, and discusses the possibility of G6PD as a diagnostic biomarker of cancer and the therapeutic potentials of G6PD inhibitors in cancer treatment. The available data show that G6PD plays a critical role in survival, proliferation, and metastasis of cancer cells. Development of potent and selective G6PD inhibitors would provide novel opportunity for cancer therapy.
代谢途径的重新编程是癌细胞病理变化的标志。某些直接控制关键代谢途径（包括糖酵解、脂肪生成和核苷酸合成）速率的基因的表达失调，使肿瘤细胞适应并进展为更具侵袭性的表型。葡萄糖-6-磷酸脱氢酶（G6PD）控制的戊糖磷酸途径在很大程度上因其作为提供还原力和核糖磷酸给细胞以维持氧化还原平衡和核苷酸和脂质的生物合成的作用而受到重视。最近，G6PD 被揭示参与细胞凋亡、血管生成和抗癌治疗的疗效，使其成为癌症治疗中一个有前途的靶点。本文综述了 G6PD 活性与癌细胞增殖、血管生成和对治疗的耐药性相关的最新进展，并讨论了 G6PD 作为癌症诊断生物标志物和 G6PD 抑制剂在癌症治疗中的治疗潜力的可能性。现有数据表明，G6PD 在癌细胞的存活、增殖和转移中起着关键作用。开发有效和选择性的 G6PD 抑制剂将为癌症治疗提供新的机会。
