一种源自非洲果蝠（Hypsignathus monstrosus）的细胞系中，一种非洲亨尼帕病毒的表面糖蛋白诱导合胞体形成。
Surface glycoproteins of an African henipavirus induce syncytium formation in a cell line derived from an African fruit bat, Hypsignathus monstrosus.
机构信息
Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany.
出版信息
J Virol. 2013 Dec;87(24):13889-91. doi: 10.1128/JVI.02458-13. Epub 2013 Sep 25.
Abstract
Serological screening and detection of genomic RNA indicates that members of the genus Henipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat, Hypsignathus monstrosus. Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.
摘要
血清学筛查和基因组 RNA 的检测表明，亨尼帕病毒属的成员不仅存在于东南亚，还存在于非洲果蝠中。我们证明，一种来自非洲果蝠（巨果蝠）的非洲亨尼帕病毒（M74）的表面糖蛋白 F 和 G 可诱导肾细胞系形成合胞体。尽管细胞嗜性较窄，但 M74 糖蛋白表现出与尼帕病毒糖蛋白的功能相似性。
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Surface glycoproteins of an African henipavirus induce syncytium formation in a cell line derived from an African fruit bat, Hypsignathus monstrosus.一种源自非洲果蝠（Hypsignathus monstrosus）的细胞系中，一种非洲亨尼帕病毒的表面糖蛋白诱导合胞体形成。
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