Istituto di Oncologia Molecolare di Fondazione Italiana per la Ricerca sul Cancro, 20139, Milan, Italy,
Histochem Cell Biol. 2013 Oct;140(4):383-93. doi: 10.1007/s00418-013-1141-6. Epub 2013 Sep 26.
The transport of proteins and lipids is one of the main cellular functions. The vesicular model, compartment (or cisterna) maturation model, and the diffusion model compete with each other for the right to be the paradigm within the field of the intra-Golgi transport. These models have significant difficulties explaining the existing experimental data. Recently, we proposed the kiss-and-run (KAR) model of intra-Golgi transport (Mironov and Beznoussenko in Int J Mol Sci 13(6):6800-6819, 2012), which can be symmetric, when fusion and fission occur in the same location, and asymmetric, when fusion and fission take place at different sites. Here, we compare the ability of main models of the intra-Golgi transport to explain the existing results examining the evidence in favor and against each model. We propose that the KAR model has the highest potential for the explanation of the majority of experimental observations existing within the field of intracellular transport.
蛋白质和脂质的运输是主要的细胞功能之一。囊泡模型、隔室（或小腔）成熟模型和扩散模型相互竞争，以成为高尔基体内部运输领域的范例。这些模型在解释现有实验数据方面存在很大困难。最近，我们提出了高尔基体内部运输的 kiss-and-run（KAR）模型（Mironov 和 Beznoussenko 在 Int J Mol Sci 13(6):6800-6819, 2012），当融合和裂变发生在同一位置时，该模型是对称的，而当融合和裂变发生在不同位置时，该模型是不对称的。在这里，我们比较了高尔基体内部运输的主要模型解释现有结果的能力，检查了每个模型的支持和反对证据。我们提出，KAR 模型最有可能解释细胞内运输领域中存在的大多数实验观察结果。
