Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269, USA.
Phys Chem Chem Phys. 2013 Nov 14;15(42):18502-9. doi: 10.1039/c3cp52193a.
Six free base tetrapyrrolic chromophores, three quinoline-annulated porphyrins and three morpholinobacteriochlorins, that absorb light in the near-IR range and possess, in comparison to regular porphyrins, unusually low fluorescence emission and (1)O2 quantum yields were tested with respect to their efficacy as novel molecular photo-acoustic imaging contrast agents in a tissue phantom, providing an up to ∼2.5-fold contrast enhancement over that of the benchmark contrast agent ICG. The testing protocol compares the photoacoustic signal output strength upon absorption of approximately the same light energy. Some relationships between photophysical parameters of the dyes and the resulting photoacoustic signal strength could be derived.
六种游离碱基四吡咯生色团、三种喹啉稠合卟啉和三种吗啉代细菌叶绿素，它们在近红外范围内吸收光，与常规卟啉相比，具有异常低的荧光发射和（1）O2 量子产率，在组织体模中作为新型分子光声成像对比剂的功效进行了测试，与基准对比剂 ICG 相比，提供了高达约 2.5 倍的对比增强。测试方案比较了吸收大致相同光能时的光声信号输出强度。可以得出染料的光物理参数与产生的光声信号强度之间的一些关系。
