Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology, CAS Key Laboratory of Health Informatics, Chinese Academy of Sciences, Shenzhen 518055, China.
Department of Chemistry, The University of Texas at Austin, 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.
J Am Chem Soc. 2020 Sep 23;142(38):16156-16160. doi: 10.1021/jacs.0c04387. Epub 2020 Sep 11.
The NIR absorptivity of the metallotexaphyrin derivatives , , and for photoacoustic (PA)-based imaging is explored in this study. All three complexes demonstrated excellent photostabilities; however, provided the greatest PA signal intensities in both doubly distilled water and RAW 264.7 cells. experiments using a prostate tumor mouse model were performed. displayed no adverse toxicity to major organs as inferred from hematoxylin and eosin (H&E) staining and cell blood count testing. also allowed for PA-based imaging of tumors with excellent stability to provide 3D tumor diagnostic information. Based on the present findings and previous magnetic resonance imaging (MRI) studies, we believe may have a role to play either as a stand-alone PA contrast agent or as a single molecule dual modal (PA and MR) imaging agent for tumor diagnosis.
本研究探索了金属四吡咯衍生物 、 和 用于光声（PA）成像的近红外吸收率。这三种配合物都表现出极好的光稳定性；然而，在双蒸水和 RAW 264.7 细胞中， 提供了最大的 PA 信号强度。使用前列腺肿瘤小鼠模型进行了 实验。从苏木精和伊红（H&E）染色和细胞血液计数测试推断， 对主要器官没有不良毒性。 还允许基于 PA 的肿瘤成像具有出色的 稳定性，以提供 3D 肿瘤诊断信息。基于目前的研究结果和以前的磁共振成像（MRI）研究，我们认为 可以作为独立的 PA 造影剂或作为用于肿瘤诊断的单分子双模（PA 和 MR）成像剂发挥作用。
