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香港前瞻性中国老年队列研究中酒精使用与呼吸疾病死亡。

Alcohol use and death from respiratory disease in a prospective Chinese elderly cohort study in Hong Kong.

机构信息

Life Course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

出版信息

Prev Med. 2013 Dec;57(6):819-23. doi: 10.1016/j.ypmed.2013.09.011. Epub 2013 Sep 25.

Abstract

OBJECTIVE

In Western settings, moderate drinking is negatively associated with respiratory disease. However, moderate drinking is socially patterned, making this association vulnerable to contextual biases. Evidence from other contexts where the typical drinking pattern is different may clarify such observations.

METHODS

Multivariable Cox regression analysis was used to assess the adjusted associations of alcohol use with death from respiratory disease using a population-based prospective cohort of 66,820 Chinese aged ≥65 years enrolled from July 1998 to December 2001 at all the 18 Elderly Health Centers of the Hong Kong Government Department of Health and followed till May 30, 2012.

RESULTS

During ten-year follow-up, 4065 deaths from respiratory disease occurred. Most current drinkers were occasional drinkers (<1 day/week). Both moderate and occasional drinking (<1 day/week) were associated with a lower risk of death from respiratory disease, but the point estimates and pattern of associations were similar between these two types of drinkers.

CONCLUSION

The typical drinking pattern, i.e. occasional drinking (<1 day/week), which is unlikely to have any biological effect, was similarly associated with a lower risk of respiratory disease as moderate alcohol use, suggesting the attributes of being a typical drinker may be protective.

摘要

目的

在西方环境中,适度饮酒与呼吸道疾病呈负相关。然而,适度饮酒具有社交模式,这使得这种关联容易受到背景偏差的影响。来自其他典型饮酒模式不同的环境的证据可能会澄清这些观察结果。

方法

使用香港政府卫生署于 1998 年 7 月至 2001 年 12 月在所有 18 个老年人健康中心招募的年龄≥65 岁的人群为基础的前瞻性队列,对 66820 名中国老年人进行多变量 Cox 回归分析,评估饮酒与呼吸道疾病死亡的调整关联。随访至 2012 年 5 月 30 日。

结果

在十年的随访中,发生了 4065 例呼吸道疾病死亡。大多数当前饮酒者为偶尔饮酒者(<1 天/周)。适度饮酒和偶尔饮酒(<1 天/周)均与呼吸道疾病死亡风险降低相关,但这两种饮酒者的点估计值和关联模式相似。

结论

典型的饮酒模式,即偶尔饮酒(<1 天/周),不太可能产生任何生物学效应,与中度饮酒一样与呼吸道疾病风险降低相关,这表明作为典型饮酒者的特征可能具有保护作用。

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