Haapasalo H, Collan Y, Seppä A, Gidlund A L, Atkin N B, Pesonen E
Department of Pathology, University of Kuopio, Finland.
Histopathology. 1990 Jan;16(1):1-7. doi: 10.1111/j.1365-2559.1990.tb01053.x.
The prognostic value of subjective histological and morphometric grading was studied in 75 primary ovarian carcinomas. Histological grading methods recommended by Czernobilsky and by Russell and the morphometric method of Baak and co-workers were compared in a two-observer system. The 5-year survival could be correctly predicted in about two-thirds of the patients with all three methods. When mitotic counting (volume corrected mitotic index, M/V-index) was compared with the above grading methods by using a receiver operating characteristic curve) the M/V-index was generally superior in its prognostic power regardless of the sensitivity/specificity level chosen. The morphometric grading method and the grading method based on the M/V index were also shown to be readily reproducible.
对75例原发性卵巢癌患者研究了主观组织学和形态计量学分级的预后价值。在双观察者系统中比较了Czernobilsky、Russell推荐的组织学分级方法以及Baak及其同事的形态计量学方法。使用这三种方法，约三分之二的患者的5年生存率能够得到正确预测。当通过绘制受试者工作特征曲线将有丝分裂计数（体积校正有丝分裂指数，M/V指数）与上述分级方法进行比较时，无论选择何种灵敏度/特异性水平，M/V指数在预后能力方面总体上更具优势。形态计量学分级方法和基于M/V指数的分级方法也显示出易于重复。
