Institute of Cell Biology and Immunology, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany.
Biochem Biophys Res Commun. 2013 Oct 18;440(2):336-41. doi: 10.1016/j.bbrc.2013.09.083. Epub 2013 Sep 25.
The neuroprotective role of TNF receptor 2 (TNFR2) has been shown in various studies. However, a direct role of TNFR2 in oligodendrocyte function has not yet been demonstrated. Using primary oligodendrocytes of transgenic mice expressing human TNFR2, we show here that TNFR2 is primarily expressed on oligodendrocyte progenitor cells. Interestingly, preconditioning with a TNFR2 agonist protects these cells from oxidative stress, presumably by increasing the gene expression of distinct anti-apoptotic and detoxifying proteins, thereby providing a potential mechanism for the neuroprotective role of TNFR2 in oligodendrocyte progenitor cells.
TNF 受体 2（TNFR2）的神经保护作用在各种研究中得到了证实。然而，TNFR2 在少突胶质细胞功能中的直接作用尚未得到证实。在这里，我们使用表达人 TNFR2 的转基因小鼠的原代少突胶质细胞表明，TNFR2 主要表达在少突胶质前体细胞上。有趣的是，TNFR2 激动剂预处理可保护这些细胞免受氧化应激，推测是通过增加特定抗凋亡和解毒蛋白的基因表达，从而为 TNFR2 在少突胶质前体细胞中的神经保护作用提供了一种潜在机制。
