Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Biomed Res Int. 2013;2013:905918. doi: 10.1155/2013/905918. Epub 2013 Sep 1.
The study was conducted to investigate whether dietary fish oil could influence growth of piglets via regulating the expression of proinflammatory cytokines. A split-plot experimental design was used with sow diet effect in the main plots and differing piglet diet effect in the subplot. The results showed that suckling piglets from fish oil fed dams grew rapidly (P < 0.05) than control. It was also observed that these piglets had higher ADG, feed intake, and final body weight (P < 0.05) during postweaning than those piglets from lard fed dams. Furthermore, there was a significant decrease (P < 0.01) in the expression of interleukin 6 and tumor necrosis factor- α in longissimus dorsi muscle. In contrast, there was a tendency (P < 0.10) towards lower ADG and higher feed:gain in weaned piglets receiving fish oil compared with those receiving lard. Meanwhile, splenic proinflammatory cytokines expression was increased (P < 0.01) in piglets receiving fish oil during postweaning period. The results suggested that 7% fish oil addition to sows' diets alleviated inflammatory response via decreasing the proinflammatory cytokines expression in skeletal muscle and accelerated piglet growth. However, 7% fish oil addition to weaned piglets' diets might decrease piglet growth via increasing splenic proinflammatory cytokines expression.
本研究旨在探讨饲粮中添加鱼油是否通过调节促炎细胞因子的表达来影响仔猪的生长。采用裂区试验设计，母猪饲粮为大区，仔猪饲粮为小区。结果表明，与对照组相比，饲喂鱼油的母猪所产仔猪生长迅速（P < 0.05）。还观察到，这些仔猪在断奶后比饲喂猪油的仔猪具有更高的平均日增重（ADG）、采食量和最终体重（P < 0.05）。此外，背最长肌中白细胞介素 6 和肿瘤坏死因子-α的表达显著降低（P < 0.01）。相反，与饲喂猪油的仔猪相比，饲喂鱼油的仔猪在断奶后 ADG 较低，饲料：增重较高（P < 0.10）。同时，在断奶后，饲喂鱼油的仔猪的脾脏促炎细胞因子表达增加（P < 0.01）。结果表明，母猪饲粮添加 7%的鱼油通过降低骨骼肌中促炎细胞因子的表达来减轻炎症反应，并加速仔猪生长。然而，在断奶仔猪饲粮中添加 7%的鱼油可能会通过增加脾脏促炎细胞因子的表达来降低仔猪的生长。
