一种源自海洋真菌曲霉属菌种的新型大环内酯类化合物
A new macrolide from a marine-derived fungus Aspergillus sp.
作者信息
Bao Jie, Xu Xin-Ya, Zhang Xiao-Yong, Qi Shu-Hua
机构信息
Key Laboratory of Marine Bio-resources Sustainable Utilization/RNAM Center for Marine Microbiology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.
出版信息
Nat Prod Commun. 2013 Aug;8(8):1127-8.
A new 16-membered macrolide named aspergillide D (1), along with six known compounds, including two polyketones (2-3) and four alkaloids (4-7), were isolated from the culture broth of a marine-derived fungus Aspergillus sp. SCSGAF 0076. The structure of 1 was elucidated on the basis of NMR and mass spectra. Compound 5 showed an obvious inhibitory effect on influenza virus strains H1N1 and H3N2.
从一株海洋来源的曲霉属真菌Aspergillus sp. SCSGAF 0076的培养液中分离出一种名为曲霉内酯D（1）的新型16元大环内酯，以及六种已知化合物，包括两种聚酮化合物（2 - 3）和四种生物碱（4 - 7）。通过核磁共振谱和质谱对1的结构进行了鉴定。化合物5对甲型流感病毒H1N1和H3N2毒株显示出明显的抑制作用。
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