Department of Oral Medicine and Diagnosis, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):702-8. doi: 10.1016/j.oooo.2013.07.004. Epub 2013 Sep 27.
This study evaluated the effect of standardized bilberry extract containing anthocyanosides on chemotherapy-induced oral mucositis in hamsters.
Twenty-four hamsters were randomly chosen and assigned to groups. Groups A and B were pretreated with deionized water, whereas group C was pretreated with bilberry extract daily for 7 days. Groups B and C underwent chemotherapy by intraperitoneal injections of 5-fluorouracil (days 4, 9, and 14); group A received normal saline. Potentiation of oral mucositis was achieved by scratching both cheek pouches of all animals with needles (days 5, 6, and 14). The pouches were histopathologically examined on day 17 after visual examination and blood sampling by cardiac puncture.
The bilberry extract group showed significantly lower oral mucositis clinical and histopathologic scores (P < .05) and less percentile of mean daily weight reductions compared with animals receiving vehicle.
Frequent administration of bilberry extract had a protective effect on oral mucosal damage induced by 5-fluorouracil in an animal model.
本研究评估了标准化含有花色苷的越桔提取物对仓鼠化疗诱导性口腔黏膜炎的影响。
随机选择 24 只仓鼠并将其分为组。A 组和 B 组用去离子水预处理，而 C 组则用越桔提取物每日预处理 7 天。B 组和 C 组通过腹腔注射氟尿嘧啶（第 4、9 和 14 天）进行化疗；A 组则给予生理盐水。通过用针刮擦所有动物的两个颊囊（第 5、6 和 14 天）来增强口腔黏膜炎。在通过心脏穿刺进行视觉检查和血液采样后的第 17 天，对囊进行组织病理学检查。
与接受载体的动物相比，越桔提取物组的口腔黏膜炎临床和组织病理学评分明显较低（P <.05），且平均每日体重减轻的百分比也较少。
在动物模型中，越桔提取物的频繁给药对 5-氟尿嘧啶引起的口腔黏膜损伤具有保护作用。
