Mahajan Aarti Sood, Jain Ak, Singh Np, Mishra Tk
Department of Physiology, Maulana Azad Medical College, New Delhi, India.
Int J Appl Basic Med Res. 2013 Jul;3(2):106-10. doi: 10.4103/2229-516X.117076.
Exercise response of asymptomatic subclinical hypothyroid patients may aid in early diagnosis of cardiovascular morbidity.
To study and compare the heart rate and blood pressure changes during exercise and recovery in subclinical hypothyroid patients and euthyroid controls.
For the study, 30 each cases (mean age of 40 ± 7 years) of subclinical hypothyroidism and healthy controls underwent exercise as per Bruce protocol. Heart rate (HR) and blood pressure (BP) changes were compared every minute (min) till 3 min of stage II exercise, continued till maximum heart rate and thereafter on recovery, for 5 min after stoppage of exercise.
Both groups had normal HR and BP at rest, heart rate and BP increased with exercise and remained high even after 5 min of recovery from exercise. The increase in systolic blood pressure (SBP) with exercise was less in patients at the stage of exercise where maximum HR was achieved and up to 1 min of recovery. SBP at 5 min of recovery was higher in patients (P = 0.018). Diastolic blood pressure (DBP) increased with exercise and changes were similar in both groups during exercise and recovery. HR was higher in patients at 1 min of exercise. Changes in HR from 1 min of recovery to 2-5 min of recovery were significant in both groups.
The present pilot study highlights that many parameters of HR and SBP during exercise and recovery in asymptomatic subclinical hypothyroid patients may differ from euthyroid, controls.
无症状亚临床甲状腺功能减退患者的运动反应可能有助于心血管疾病的早期诊断。
研究并比较亚临床甲状腺功能减退患者和甲状腺功能正常对照组在运动及恢复过程中的心率和血压变化。
本研究中，30例亚临床甲状腺功能减退患者（平均年龄40±7岁）和30例健康对照者按照布鲁斯方案进行运动。在运动至II期3分钟前每分钟比较心率（HR）和血压（BP）变化，持续至最大心率，之后运动停止后恢复5分钟期间持续比较。
两组在静息时心率和血压均正常，运动时心率和血压升高，运动恢复5分钟后仍保持较高水平。在达到最大心率的运动阶段及恢复1分钟内，患者运动时收缩压（SBP）的升高幅度较小。患者在恢复5分钟时的SBP更高（P = 0.018）。舒张压（DBP）随运动升高，两组在运动及恢复过程中的变化相似。患者在运动1分钟时心率更高。两组从恢复1分钟到恢复2 - 5分钟时心率的变化均显著。
本初步研究强调，无症状亚临床甲状腺功能减退患者在运动及恢复过程中的许多心率和收缩压参数可能与甲状腺功能正常的对照组不同。
