1 Pfizer Inc. , New York, New York.
J Womens Health (Larchmt). 2013 Nov;22(11):983-90. doi: 10.1089/jwh.2012.3719. Epub 2013 Oct 1.
The aim of this study was to investigate the impact of menopausal symptoms and menopausal symptom severity on health-related quality of life (HRQoL), work impairment, healthcare utilization, and costs.
Data from the 2005 United States National Health and Wellness Survey were used, with only women 40-64 years without a history of cancer included in the analyses (N=8,811). Women who reported experiencing menopausal symptoms (n=4,116) were compared with women not experiencing menopausal symptoms (n=4,695) on HRQoL, work impairment, and healthcare utilization using regression modeling (and controlling for demographics and health characteristic differences). Additionally, individual menopausal symptoms were used as predictors of outcomes in a separate set of regression models.
The mean age of women in the analysis was 49.8 years (standard deviation,±5.9). Women experiencing menopausal symptoms reported significantly lower levels of HRQoL and significantly higher work impairment, and healthcare utilization than women without menopausal symptoms. Depression, anxiety, and joint stiffness were symptoms with the strongest associations with health outcomes.
Menopausal symptoms can be a significant humanistic and economic burden on women in middle age.
本研究旨在探讨绝经症状及其严重程度对健康相关生活质量（HRQoL）、工作障碍、医疗保健利用和成本的影响。
本研究使用了 2005 年美国国家健康与健康调查的数据，仅纳入了 40-64 岁且无癌症史的女性（N=8811）。通过回归模型（并控制人口统计学和健康特征差异），比较了报告有绝经症状（n=4116）和无绝经症状（n=4695）的女性在 HRQoL、工作障碍和医疗保健利用方面的差异。此外，在另一组回归模型中，将个别绝经症状作为结果的预测因子。
分析中女性的平均年龄为 49.8 岁（标准差，±5.9）。有绝经症状的女性报告的 HRQoL 明显较低，工作障碍和医疗保健利用率明显较高。抑郁、焦虑和关节僵硬是与健康结果相关性最强的症状。
绝经症状可能会给中年女性带来重大的人文和经济负担。
