J Clin Invest. 2013 Oct;123(10):4121-30. doi: 10.1172/JCI67714. Epub 2013 Oct 1.
Since the discovery of hepatitis C virus (HCV) by molecular cloning almost a quarter of a century ago, unprecedented at the time because the virus had never been grown in cell culture or detected serologically, there have been impressive strides in many facets of our understanding of the natural history of the disease, the viral life cycle, the pathogenesis, and antiviral therapy. It is apparent that the virus has developed multiple strategies to evade immune surveillance and eradication. This Review covers what we currently understand of the temporal and spatial immunological changes within the human innate and adaptive host immune responses that ultimately determine the outcomes of HCV infection.
自四分之一个世纪前通过分子克隆发现丙型肝炎病毒 (HCV) 以来，由于该病毒从未在细胞培养中生长或通过血清学检测到，这在当时是前所未有的，我们在疾病的自然史、病毒生命周期、发病机制和抗病毒治疗等多个方面都取得了令人瞩目的进展。显然，该病毒已经发展出多种策略来逃避免疫监视和清除。这篇综述涵盖了我们目前对人类先天和适应性宿主免疫反应中时空免疫变化的理解，这些变化最终决定了 HCV 感染的结果。
