Shalev Y, Bentwich Z, Katz D, Brautbar C, Mozes E
Clin Exp Immunol. 1985 May;60(2):355-62.
Thirty-three Israeli patients with systemic lupus erythematosus (SLE) were studied for their ability to respond to the synthetic polypeptide poly (Tyr,Glu)-poly (DLAla)-poly(Lys) [( T,G]-A-L) as measured by the production of a T cell helper factor by their antigen activated T cells. Twenty-seven of the patients were typed for their HLA phenotypes. Nineteen patients were with more active disease and 14 with a milder non-active disease. All the patients of the two groups responded to (T,G)-A-L by the production of an antigen specific helper T cell factor, in contrast to only 50% responders among healthy donors. Thus, lack of normal regulation of T cell helper function was observed among all patients with SLE, independently of their disease activity and/or treatment. A higher frequency of DR5 (75%) was observed in patients with a milder non-active disease (vs 46.6% in normal healthy control individuals) while 53.3% of patients with active disease possessed DR7 (21.8% in controls). These findings may suggest a possible association between the severity of the disease and a specific DR determinant.
对33名以色列系统性红斑狼疮（SLE）患者进行了研究，以检测其抗原激活的T细胞产生T细胞辅助因子的能力，从而评估他们对合成多肽聚（酪氨酸，谷氨酸）-聚（D-丙氨酸）-聚（赖氨酸）[（T，G）-A-L]的反应。对其中27名患者进行了HLA表型分型。19名患者病情较为活跃，14名患者病情较轻且不活跃。与健康供体中只有50%有反应者不同，两组所有患者通过产生抗原特异性辅助性T细胞因子对（T，G）-A-L产生反应。因此，在所有SLE患者中均观察到T细胞辅助功能缺乏正常调节，这与他们的疾病活动度和/或治疗无关。病情较轻且不活跃的患者中DR5频率较高（75%）（正常健康对照个体中为46.6%），而病情活跃的患者中有53.3%拥有DR7（对照中为21.8%）。这些发现可能提示疾病严重程度与特定DR决定簇之间可能存在关联。
