中文语境下的 HLA 与系统性红斑狼疮。
HLA and systemic lupus erythematosus in Chinese.
作者信息
Chan S H, Feng P H, Srinivasan N, Wee G B, Chan H C
出版信息
Hum Immunol. 1981 Dec;3(4):345-50. doi: 10.1016/0198-8859(81)90070-7.
Seventy-five unrelated Chinese SLE patients were HLA typed and subdivided into mild and severe disease. The HLA-B13 was associated with mild disease. Fourteen of 30 (46.7%) mild disease patients had B13 compared to 63/330 (19.1%) normal subjects (p less than 0.0005, corrected p less than 0.013, RR = 3.7). The HLA-B17 on the other hand was observed in 29% of 45 severe disease patients compared to 13.9% of 330 normal subjects (p less than 0.01, RR = 2.5). The frequency of HLA-B17 in 11 patients who died was even higher (45.5%).
对75名无亲缘关系的中国系统性红斑狼疮（SLE）患者进行了人类白细胞抗原（HLA）分型，并将其分为轻症和重症两组。HLA - B13与轻症疾病相关。30名轻症患者中有14名（46.7%）携带B13，而330名正常受试者中有63名（19.1%）携带B13（p < 0.0005，校正后p < 0.013，相对危险度RR = 3.7）。另一方面，45名重症患者中有29%观察到HLA - B17，而330名正常受试者中有13.9%携带该抗原（p < 0.01，RR = 2.5）。11名死亡患者中HLA - B17的频率甚至更高（45.5%）。
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