Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Kyoto University.
Biol Pharm Bull. 2013;36(10):1608-14. doi: 10.1248/bpb.b13-00491.
The aromatherapeutical potential of Piper guineense essential oil was investigated in mice via inhalation administration, and the active compounds were identified. An open field test and light/dark transition test were used to evaluate the sedative and anxiolytic activities of this essential oil, respectively. P. guineense essential oil showed significant sedative activity at an effective dose of 4.0 × 10(-5) mg per cage compared to the control group. It also showed potent anxiolytic effect at a dose of 4.0 × 10(-6) mg per cage. The main compounds of P. guineense essential oil were linalool (41.8%) and 3,5-dimethoxytoluene (10.9%). These two main compounds were shown to play a major role in the sedative activity of P. guineense essential oil. These results suggest that inhalation of P. guineense essential oil might induce a mild tranquilizing effect.
采用吸入给药方式研究了几内亚胡椒精油的芳香疗法潜力，并鉴定了其活性化合物。通过旷场试验和明暗穿梭试验分别评估了该精油的镇静和抗焦虑活性。与对照组相比，4.0×10(-5)mg/笼的有效剂量下，几内亚胡椒精油表现出显著的镇静活性。在 4.0×10(-6)mg/笼的剂量下，它也表现出很强的抗焦虑作用。几内亚胡椒精油的主要成分是芳樟醇（41.8%）和 3,5-二甲氧基甲苯（10.9%）。这两种主要成分被证明在几内亚胡椒精油的镇静活性中起主要作用。这些结果表明，吸入几内亚胡椒精油可能会引起轻微的镇静作用。
