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蒙古国社区获得性肺炎(CAP)处方实践评估。

An evaluation of prescribing practices for community-acquired pneumonia (CAP) in Mongolia.

机构信息

School of Pharmacy, Curtin University, Bentley, Western Australia, Australia.

出版信息

BMC Health Serv Res. 2013 Oct 3;13:379. doi: 10.1186/1472-6963-13-379.

Abstract

BACKGROUND

Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality in all age groups worldwide. It may be classified as mild/moderate or severe, the latter usually requiring hospitalisation. Although, there are many studies reported in relation to CAP, there is relatively little known about the treatment of CAP and its antibiotic use in Mongolia. The study aim was to evaluate prescribing practices for the treatment of mild/moderate CAP in Mongolia with respect to national prescribing guidelines.

METHODS

Written prescriptions with a written diagnosis of CAP included were collected prospectively and sequentially for ten weeks from a purposefully selected sample of community pharmacies in rural and urban areas of Mongolia. The data collected included the patient's age, gender, medication details, frequency and number of doses prescribed. Evaluation was with respect to the Mongolian Standard Treatment Guidelines (2005, 2008). Statistical differences between groups were tested using the Chi-squared and Fisher's exact tests.

RESULTS

Prescriptions were collected from 22 pharmacies and represented the prescribing practices of 118 doctors. The study enrolled 394 (193 adults and 201 children) patients, with a median age for children of 2.0 years (range: 0.03-12) and adults of 33.0 years (range: 13-92).The most commonly prescribed drugs were aminopenicillins, vitamins, and mucolytics, with the median number of drugs being three per prescription. Inappropriate drug selection was similar for adults (57.7%) and children (56.6%), and the major reason for an overall frequency of inappropriate prescribing for adults was 89.0% and for children 78.0%. Doctors in urban areas prescribed more inappropriate drugs than those in rural areas for both children and adults, p = .0014. The proportion of prescribed injections was 28.4% for adults and 9.0% for children, and for adults was significantly higher in urban areas. The prescribing standard for non-hospitalized patients in Mongolia states that injections should not be prescribed.

CONCLUSIONS

The high level of inappropriate prescribing for mild/moderate CAP highlights the need to develop comprehensive and reliable procedures nationwide to improve prescribing practices in Mongolia.

摘要

背景

社区获得性肺炎(CAP)是全球各年龄段人群发病率和死亡率的重要原因。它可以分为轻度/中度或重度,后者通常需要住院治疗。尽管已经有许多关于 CAP 的研究报告,但对于蒙古的 CAP 治疗及其抗生素使用情况,人们知之甚少。本研究旨在评估蒙古治疗轻度/中度 CAP 的处方实践,以符合国家处方指南。

方法

从蒙古农村和城市地区有针对性选择的社区药店中,前瞻性地连续收集了十周内带有 CAP 书面诊断的书面处方。收集的数据包括患者的年龄、性别、用药详情、规定的用药频次和剂量。评估标准是基于 2005 年和 2008 年蒙古标准治疗指南。使用卡方检验和 Fisher 确切检验对组间的差异进行统计学检验。

结果

从 22 家药店收集了处方,代表了 118 名医生的处方实践。该研究共纳入了 394 名(193 名成人和 201 名儿童)患者,儿童的中位年龄为 2.0 岁(范围:0.03-12),成人的中位年龄为 33.0 岁(范围:13-92)。最常开的药物是氨基青霉素类、维生素和黏液溶解剂,每张处方的平均用药数量为三种。成人和儿童的药物选择不当比例相似(57.7%和 56.6%),成人和儿童开处方不当的主要原因分别为 89.0%和 78.0%。城市地区医生为儿童和成人开具的不当药物多于农村地区,p =.0014。成人开具的注射剂比例为 28.4%,儿童为 9.0%,城市地区显著更高。蒙古非住院患者的处方标准规定不应开具注射剂。

结论

对于轻度/中度 CAP 的高比例不适当处方表明,需要在全国范围内制定全面可靠的程序,以改善蒙古的处方实践。

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