Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea.
Vet Res. 2013 Oct 3;44(1):92. doi: 10.1186/1297-9716-44-92.
Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs of infected dogs, the genes associated with the immune response and cell death were greatly elevated. Taken together, our results suggest that canine H3N2 influenza virus can be easily transmitted among dogs, and that severe pneumonia in the infected dogs may be partially due to the elevated expression of genes related to inflammation and apoptosis.
狗是与人类生活密切相关的伴侣动物。从表现出严重呼吸道症状和其他临床症状（如发热、体重减轻和间质性肺炎）的宠物狗中分离到了犬 H3N2 流感病毒。犬 H3N2 流感病毒可以通过气溶胶在狗之间高度传播。当我们分析感染狗的肺部的全球基因表达时，与免疫反应和细胞死亡相关的基因大大上调。综上所述，我们的结果表明，犬 H3N2 流感病毒可以在狗之间轻松传播，感染狗的严重肺炎可能部分是由于与炎症和细胞凋亡相关的基因表达上调所致。
