Akbal Ayla, Tutkun Engin, Yılmaz Hınç
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Çanakkale Onsekiz Mart University , Çanakkale , Turkey and.
Aging Male. 2014 Sep;17(3):189-93. doi: 10.3109/13685538.2013.836482. Epub 2013 Oct 3.
Lead exposure linked to osteoporosis in women. However, there is no direct evidence whether lead exposure has effects on bone metabolism in middle-aged male subjects. Therefore, the present study investigated the relationship between bone mineral densitometry measurements, bone markers, endocrine hormones and blood lead levels.
The present study included lead exposure patients (n: 30) and control subjects (n: 32). We recorded information on patient demographics and risk factors of osteoporosis. Blood lead levels were evaluated using Varian AA 240Z atomic absorption spectrophotometry. Bone mineral density measurements were measured using dual-energy X-ray absorptiometry.
Each lumbar T and Z scores in the lead exposure group were lower than the control group. There were no significant differences in femur neck and femur total T and Z scores between two groups. Blood lead levels were also negatively correlated with lumbar 2-4 T score, total lumbar T score, lumbar 2-4 Z score and total lumbar Z score. Urinary hydroxyproline and urinary deoxypyridinoline levels in the lead exposure group were significantly higher compared to controls. Blood lead levels were strong, positively correlated with urinary deoxypyridinoline. Endocrine hormone levels and 1,25-dihydroxy-vitamin D3 levels were comparable between lead exposure and control group.
Lead exposure in male workers is an important factor for deterioration in bone mineral density. We should be screening blood lead levels and history of lead exposure in male osteoporosis.
铅暴露与女性骨质疏松症有关。然而，尚无直接证据表明铅暴露对中年男性受试者的骨代谢有影响。因此，本研究调查了骨密度测量、骨标志物、内分泌激素与血铅水平之间的关系。
本研究纳入铅暴露患者（n = 30）和对照组受试者（n = 32）。我们记录了患者的人口统计学信息和骨质疏松症的危险因素。使用瓦里安AA 240Z原子吸收分光光度法评估血铅水平。使用双能X线吸收法测量骨密度。
铅暴露组的每个腰椎T值和Z值均低于对照组。两组之间股骨颈和股骨整体的T值和Z值无显著差异。血铅水平也与腰椎2 - 4的T值、腰椎总T值、腰椎2 - 4的Z值和腰椎总Z值呈负相关。与对照组相比，铅暴露组的尿羟脯氨酸和尿脱氧吡啶啉水平显著更高。血铅水平与尿脱氧吡啶啉呈强正相关。铅暴露组和对照组之间的内分泌激素水平和1,25 - 二羟基维生素D3水平相当。
男性工人的铅暴露是骨密度下降的一个重要因素。在男性骨质疏松症中，我们应该筛查血铅水平和铅暴露史。
