糙皮侧耳水提物对实验性糖尿病大鼠的降血糖和降血脂作用。
Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats.
机构信息
Department of Clinical Laboratory, High Vocational Technological College, China Medical University, North Bei'er Road, No, 92, Shenyang 110001, Liaoning, PR China.
出版信息
BMC Complement Altern Med. 2013 Oct 3;13:253. doi: 10.1186/1472-6882-13-253.
BACKGROUND
Hericium erinaceus, as a commonly used medicine or food, has attracted much attention due to its health effects when used as a home remedy for some diseases. The aim of this work was to investigate the hypoglycemic and hypolipidemic effects of aqueous extract of Hericium erinaceus (AEHE) in streptozotocin (STZ)-induced diabetic rats.
METHODS
Diabetes was induced in Wistar rats by the administration of STZ (55 mg/kg BW.) intraperitoneally. AEHE (100 and 200 mg/kg BW.) was administered for a period of 28 days. The effects of AEHE on glucose, insulin, and lipid files in blood, and oxidative stress parameters in the liver were evaluated. The body weights of rats were recorded at day 0, 14 and 28th days.
RESULTS
The administration of AEHE for 28 days in STZ diabetic rats resulted in a significant decrease in serum glucose level and a significant rise in serum insulin level. AEHE treatment attenuated lipid disorders. In addition, AEHE administration increased the activities of CAT, SOD, and GSH-Px, and GSH level, and reduced MDA level in the liver tissue significantly.
CONCLUSION
Our results suggest that AEHE possesses hypoglycemic, hypolipidemic, and antioxidant properties in STZ-induced diabetes rats.
背景
由于其作为一些疾病的家庭疗法的健康功效，作为一种常用的药物或食品，猴头菇引起了广泛关注。本工作旨在研究猴头菇水提物（AEHE）对链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖和降血脂作用。
方法
通过腹腔内给予 STZ（55mg/kg BW.）诱导 Wistar 大鼠糖尿病。给予 AEHE（100 和 200mg/kg BW.）28 天。评估 AEHE 对血糖、胰岛素和血液脂质谱以及肝脏氧化应激参数的影响。在第 0、14 和 28 天记录大鼠的体重。
结果
AEHE 连续给药 28 天可显著降低 STZ 糖尿病大鼠的血清葡萄糖水平，并显著升高血清胰岛素水平。AEHE 治疗可减轻脂质紊乱。此外，AEHE 给药可显著增加肝组织中的 CAT、SOD、GSH-Px 和 GSH 水平，并降低 MDA 水平。
结论
我们的结果表明，AEHE 对 STZ 诱导的糖尿病大鼠具有降血糖、降血脂和抗氧化作用。
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