Zhang Hongtuan, Qi Can, Wang Andi, Li Liang, Xu Yong
National Key Clinical Specialty of Urology, Second Affiliated Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, 23 Pingjiang Road, Hexi District, Tianjin, 300211, China.
Tumour Biol. 2014 Mar;35(3):2025-8. doi: 10.1007/s13277-013-1268-z. Epub 2013 Oct 4.
Nucleobindin 2 (NUCB2) has been demonstrated to play critical roles in tumorigenesis and tumor development of breast cancer. The expression change of nucleobindin 2 at mRNA level in prostate cancer (PCa) tissues compared with adjacent benign prostate tissues was detected by using real-time quantitative reverse transcriptase-polymerase chain reaction analysis in our previous study. The data suggests that NUCB2 is a cancer-related gene associated with the aggressive progression and biochemical recurrence-free survival predictor of PCa patients. However, the correlation between the expression of the NUCB2 mRNA and the overall survival of patients with PCa was not analyzed. Thus, the association of NUCB2 mRNA expression with overall survival of PCa patients was analyzed in this study. Kaplan-Meier analysis and Cox proportional hazards regression models were used to investigate the correlation between NUCB2 mRNA expression and prognosis of PCa patients. The Kaplan-Meier survival analysis showed that the high expression of NUCB2 was related to the poor overall survival of patients with PCa. Multivariate Cox analysis showed that NUCB2 mRNA was an independent prognostic factor for overall survival of patients with PCa. In conclusion, we demonstrated that high NUCB2 mRNA expression correlated with poor overall survival in patients with PCa.
核结合蛋白2（NUCB2）已被证明在乳腺癌的肿瘤发生和肿瘤发展中起关键作用。在我们之前的研究中，通过实时定量逆转录聚合酶链反应分析检测了前列腺癌（PCa）组织与相邻良性前列腺组织相比核结合蛋白2在mRNA水平的表达变化。数据表明，NUCB2是一个与PCa患者的侵袭性进展和无生化复发生存预测相关的癌症相关基因。然而，未分析NUCB2 mRNA表达与PCa患者总生存期之间的相关性。因此，本研究分析了NUCB2 mRNA表达与PCa患者总生存期的关联。采用Kaplan-Meier分析和Cox比例风险回归模型来研究NUCB2 mRNA表达与PCa患者预后的相关性。Kaplan-Meier生存分析表明，NUCB2的高表达与PCa患者较差的总生存期相关。多变量Cox分析表明，NUCB2 mRNA是PCa患者总生存期的独立预后因素。总之，我们证明了PCa患者中NUCB2 mRNA的高表达与较差的总生存期相关。
