前列腺癌中 NUCB2 mRNA 表达的临床意义。
Clinical significance of NUCB2 mRNA expression in prostate cancer.
机构信息
National Key Clinical Specialty of Urology, Tianjin Key Institute of Urology, Second Affiliated Hospital of Tianjin Medical University, China.
出版信息
J Exp Clin Cancer Res. 2013 Aug 16;32(1):56. doi: 10.1186/1756-9966-32-56.
BACKGROUND
Nucleobindin 2 (NUCB2) abnormal expression has been reported in gastric cancer and breast cancer. However, the role of NUCB2 in prostate cancer (PCa) remains unclear. The aim of the present study was to investigate the NUCB2 expression in PCa tissues and adjacent non-cancerous tissues and its potential relevance to clinicopathological variables and prognosis.
METHODS
NUCB2 mRNA expression was determined by real-time quantitative real time reverse transcriptase polymerase chain reaction in 180 pairs of fresh frozen PCa tissues and corresponding non-cancerous tissues. Kaplan-Meier analysis and Cox proportional hazards regression models were used to investigate the correlation between NUCB2 expression and prognosis of PCa patients.
RESULTS
Our results showed that the expression level of NUCB2 mRNA in PCa tissues was significantly higher than those in non-cancerous tissues. Our results indicated that the high expression of NUCB2 in PCa was associated with lymph node metastasis, preoperative PSA, Gleason score, and angiolymphatic invasion. Kaplan-Meier survival analysis showed that patients with high NUCB2 expression have shorter biochemical recurrence (BCR)-free survival time compared to patients with low NUCB2 expression. Multivariate analysis revealed that NUCB2 expression was an independent predictor of BCR-free survival.
CONCLUSIONS
NUCB2 might play a positive role in PCa development and could serve as an independent predictor of BCR-free survival.
背景
核结合蛋白 2（NUCB2）在胃癌和乳腺癌中的异常表达已有报道。然而，NUCB2 在前列腺癌（PCa）中的作用尚不清楚。本研究旨在探讨 NUCB2 在 PCa 组织和相邻非癌组织中的表达及其与临床病理变量和预后的潜在相关性。
方法
通过实时定量实时逆转录聚合酶链反应，在 180 对新鲜冷冻的 PCa 组织和相应的非癌组织中测定 NUCB2 mRNA 的表达。采用 Kaplan-Meier 分析和 Cox 比例风险回归模型来研究 NUCB2 表达与 PCa 患者预后的相关性。
结果
我们的结果表明，PCa 组织中 NUCB2 mRNA 的表达水平明显高于非癌组织。我们的结果表明，PCa 中 NUCB2 的高表达与淋巴结转移、术前 PSA、Gleason 评分和血管淋巴管侵犯有关。Kaplan-Meier 生存分析表明，NUCB2 高表达的患者生化无复发生存时间（BCR）明显短于 NUCB2 低表达的患者。多因素分析显示，NUCB2 表达是 BCR 无复发生存的独立预测因子。
结论
NUCB2 可能在 PCa 发展中起积极作用，并可作为 BCR 无复发生存的独立预测因子。
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