Division of Endocrinology and Metabolism, Departments of Medicine, Community Health Sciences and Oncology, University of Calgary, Calgary, AB, Canada.
J Clin Densitom. 2013 Oct-Dec;16(4):420-5. doi: 10.1016/j.jocd.2013.08.014. Epub 2013 Oct 2.
A popular concept in nutrition and lay literature is that of the role of a diet high in acid or protein in the pathogenesis of osteoporosis. A diet rich in fruit and vegetable intake is thought to enhance bone health as the result of its greater potassium and lower "acidic" content than a diet rich in animal protein and sodium. Consequently, there have been a number of studies of diet manipulation to enhance potassium and "alkaline" content of the diet to improve bone density or other parameters of bone health. Although acid loading or an acidic diet featuring a high protein intake may be associated with an increase in calciuria, the evidence supporting a role of these variables in the development of osteoporosis is not consistent. Similarly, intervention studies with a more alkaline diet or use of supplements of potassium citrate or bicarbonate have not consistently shown a bone health benefit. In the elderly, inadequate protein intake is a greater problem for bone health than protein excess.
在营养和大众文献中，一个流行的概念是，高酸或高蛋白饮食在骨质疏松症的发病机制中起作用。人们认为，富含水果和蔬菜的饮食由于钾含量较高，“酸性”物质较少，而动物蛋白和钠含量较高的饮食能促进骨骼健康。因此，有许多关于饮食干预的研究，旨在提高饮食中的钾和“碱性”物质含量，以改善骨密度或其他骨骼健康参数。尽管酸性负荷或高蛋白饮食可能与钙排泄增加有关，但支持这些变量在骨质疏松症发展中起作用的证据并不一致。同样，采用更碱性饮食或补充柠檬酸钾或碳酸氢盐的干预研究也没有一致显示对骨骼健康有益。在老年人中，蛋白质摄入不足对骨骼健康的影响大于蛋白质过剩。
