Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, Republic of Korea; Department of Biomedical Engineering, University of Science and Technology (UST), Seoul 136-791, Republic of Korea.
Biomaterials. 2014 Jan;35(1):440-9. doi: 10.1016/j.biomaterials.2013.09.054. Epub 2013 Oct 4.
Lanthanide ion-doped nanophosphors are an emerging group of nanomaterials with excellent optical properties, and have been suggested as alternatives to quantum dots. In this letter, we determine the in-vitro and in-vivo toxicity of β-NaYF4:Ce,Tb nanophosphors using Capan-1 cells and embryonic zebrafish, respectively. In particular, we are the first to report on the in-vivo toxicity of β-phase nanophosphors and examine phenotypic developmental abnormalities (growth retardation, heart deformity, and bent tail), apoptotic cell death, and changes in heart function due to the nanophosphors. This study suggests the use of β-NaYF4:Ce,Tb nanophosphors as alternatives for QDs in a wide variety of biomedical imaging applications.
镧系离子掺杂纳米荧光粉是一类具有优异光学性能的新型纳米材料，被认为是量子点的替代品。在本研究中，我们分别使用 Capan-1 细胞和胚胎斑马鱼来确定β-NaYF4:Ce,Tb 纳米荧光粉的体外和体内毒性。特别地，我们首次报道了β相纳米荧光粉的体内毒性，并研究了由于纳米荧光粉导致的斑马鱼表型发育异常（生长迟缓、心脏畸形和弯曲的尾巴）、细胞凋亡和心脏功能变化。本研究表明，β-NaYF4:Ce,Tb 纳米荧光粉可在各种生物医学成像应用中替代量子点。
