Toronto Western Research Institute, University Health Network, University of Toronto, Canada.
Exp Neurol. 2013 Dec;250:221-7. doi: 10.1016/j.expneurol.2013.09.018. Epub 2013 Oct 2.
The effects of subthalamic nucleus (STN) stimulation on the pedunculopontine nucleus area (PPNR) evoked activities were examined in two patients with Parkinson's disease. The patients had previously undergone bilateral STN deep brain stimulation (DBS) and subsequently received unilateral DBS electrodes in the PPNR. Evoked potentials were recorded from the local field potentials (LFP) from the PPNR with STN stimulation at different frequencies and bipolar contacts. Ipsilateral and contralateral short latency (<2ms) PPNR responses were evoked from left but not from right STN stimulation. In both patients, STN stimulation evoked contralateral PPNR responses at medium latencies between 41 and 45ms. Cortical evoked potentials to single pulse STN stimulation were observed at latencies between 18 and 27ms. These results demonstrate a functional connection between the STN and the PPNR. It likely involves direct projections between the STN and PPNR or polysynaptic pathways with thalamic or cortical relays.
我们在两名帕金森病患者中研究了丘脑底核（STN）刺激对动眼神经核区（PPNR）诱发活动的影响。这些患者之前接受过双侧 STN 深部脑刺激（DBS）治疗，随后在 PPNR 中接受了单侧 DBS 电极刺激。通过记录来自 PPNR 的局部场电位（LFP），在不同频率和双极接触下，对 STN 刺激进行了诱发电位的记录。左侧但不是右侧 STN 刺激可诱发同侧短潜伏期（<2ms）PPNR 反应。在两名患者中，STN 刺激在 41 到 45ms 之间的中潜伏期诱发了对侧 PPNR 反应。在潜伏期 18 到 27ms 之间观察到皮质对单脉冲 STN 刺激的诱发电位。这些结果表明 STN 和 PPNR 之间存在功能连接。这可能涉及 STN 和 PPNR 之间的直接投射，或者是具有丘脑或皮质中继的多突触通路。
