谷氨酸转运体同源物的底物诱导重排。
Substrate-induced rearrangements in glutamate-transporter homologs.
机构信息
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
出版信息
Nat Struct Mol Biol. 2013 Oct;20(10):1142-4. doi: 10.1038/nsmb.2685.
PMID:24096399
Abstract
Sodium-coupled glutamate transporters regulate excitatory signaling in the brain. A new crystal structure shows how the substrate induces changes in the binding pocket of an archaeal transporter homolog, providing new insights into the mechanism of transport.
摘要
钠离子依赖型谷氨酸转运体调节大脑中的兴奋性信号。一个新的晶体结构显示了底物如何诱导古菌转运体同源物结合口袋的变化，为转运机制提供了新的见解。
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