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卵母细胞玻璃化:从基础科学到临床应用。

Vitrification of oocytes: from basic science to clinical application.

机构信息

FertileSafe, Shlomzion Hamalca 59/5, Tel Aviv, 62266, Israel,

出版信息

Adv Exp Med Biol. 2013;761:69-83. doi: 10.1007/978-1-4614-8214-7_6.

DOI:10.1007/978-1-4614-8214-7_6
PMID:24097382
Abstract

Vitrification is a physical process by which a liquid is transformed into a solid of amorphous glass form. It was only at the end of the nineteenth century (1898) that Gustav Heinrich Johann Apollon Tammann pointed out that a large number of substances can be obtained as glasses and suggested that this property might be universal (Tammann, Zeitschrift for Physikalische Chemie; 25: 441-479, 1898). Basically, vitrification is the supercooling of a liquid to a temperature at which the viscosity is so high that it can be defined as being at a solid state. The understanding of the vitrification process has been deepened over the years and has been applied for cryopreservation and currently is the method of choice for preserving oocytes and embryos.

摘要

玻璃化是一种将液体转变为无定形玻璃态固体的物理过程。直到 19 世纪末(1898 年),古斯塔夫·海因里希·约翰·阿普尔顿·坦曼才指出,大量物质可以被制成玻璃,并提出这种特性可能具有普遍性(坦曼,《物理化学杂志》;25:441-479,1898 年)。基本上,玻璃化是将液体冷却到粘度如此之高的温度,以至于可以定义为处于固态。多年来,人们对玻璃化过程的理解不断加深,并将其应用于冷冻保存,目前是保存卵母细胞和胚胎的首选方法。

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1
Vitrification of oocytes: from basic science to clinical application.卵母细胞玻璃化:从基础科学到临床应用。
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Animal oocyte and embryo cryopreservation.动物卵母细胞和胚胎冷冻保存。
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Ice formation and its elimination in cryopreservation of oocytes.卵母细胞冷冻保存中的结冰及其消除
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Cryopreservation by Directional Freezing and Vitrification Focusing on Large Tissues and Organs.定向冷冻和玻璃化冷冻保存,重点关注大型组织和器官。
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The Near Future of Vitrification of Oocytes and Embryos: Looking into Past Experience and Planning into the Future.卵母细胞和胚胎玻璃化的近期未来:回顾过去经验并规划未来
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Effects of vitrification and a Rho-associated coiled-coil containing protein kinase 1 inhibitor on the meiotic and developmental competence of feline oocytes.玻璃化冷冻和一种含Rho相关卷曲螺旋蛋白激酶1抑制剂对猫卵母细胞减数分裂及发育能力的影响。
J Reprod Dev. 2017 Oct 18;63(5):511-517. doi: 10.1262/jrd.2017-004. Epub 2017 Aug 11.
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Chin Med J (Engl). 2015 Feb 5;128(3):390-7. doi: 10.4103/0366-6999.150115.
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Fine morphological assessment of quality of human mature oocytes after slow freezing or vitrification with a closed device: a comparative analysis.使用封闭装置对人类成熟卵母细胞进行慢速冷冻或玻璃化冷冻后的形态学质量精细评估:一项比较分析
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