Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Level 3, Medical School South, Frome Rd., Adelaide 5005, Australia.
Hum Reprod Update. 2014 Jan-Feb;20(1):29-39. doi: 10.1093/humupd/dmt049. Epub 2013 Oct 4.
The remodelling of the blood vasculature has been the subject of much research while rapid progress in the understanding of the factors controlling lymphangiogenesis in the ovary has only been reported more recently. The ovary undergoes cyclic remodelling throughout each menstrual/estrous cycle. This process requires significant vascular remodelling to supply each new cohort of growing follicles.
Literature searches were performed to review studies on the ovarian lymphatic vasculature that described spatial, temporal and functional data in human or animal species. The role of ovarian blood and lymphatic vasculature in the pathogenesis of ovarian disease and dysfunction was also explored.
Research in a number of species including zebrafish, rodents and primates has described the lymphatic vasculature within the remodelling ovary, while recent research in mouse has confirmed hormonal regulation of lymphangiogenic growth factors, their receptors and also a role for the protease, ADAMTS1 in the development of the lymphatic vasculature. With a critical role in the maintenence of fluid homeostasis, the ovarian lymphatic vasculature is important for normal ovarian function and has been linked to syndromes involving ovarian fluid imbalance, including ovarian hyperstimulation syndrome and massive ovarian edema. The lymphatic vasculature has also been heavily implicated in the metastatic cancer process.
The spatial and temporal regulation of the ovarian lymphatic vasculature has now been reported in a number of species and the data also implicate the ovarian lymphatic vasculature in ovarian pathologies, including cancer and those linked with use of artificial reproduction technologies.
血管重构一直是研究的主题，而最近才报道了对卵巢淋巴管生成控制因素的理解取得了快速进展。卵巢在每个月经/发情周期中经历周期性重构。这个过程需要显著的血管重构来为每个新的生长卵泡群提供营养。
进行了文献检索，以综述描述人类或动物物种中空间、时间和功能数据的卵巢淋巴管血管研究。还探讨了卵巢血管和淋巴管在卵巢疾病和功能障碍发病机制中的作用。
包括斑马鱼、啮齿动物和灵长类动物在内的许多物种的研究描述了重构卵巢内的淋巴管血管，而最近在小鼠中的研究证实了激素对淋巴管生成生长因子及其受体的调节作用，以及蛋白酶 ADAMTS1 在淋巴管血管发育中的作用。卵巢淋巴管血管在维持液体动态平衡方面起着至关重要的作用，对于正常的卵巢功能很重要，并且与涉及卵巢液失衡的综合征有关，包括卵巢过度刺激综合征和卵巢水肿。淋巴管血管也与转移性癌症过程密切相关。
已经在许多物种中报道了卵巢淋巴管血管的时空调节，并且数据还表明卵巢淋巴管血管参与了包括癌症和与人工生殖技术使用相关的那些卵巢病理学。
