Preventive Cardiology Program, Columbia University Medical Center/New York-Presbyterian Hospital, New York, NY, USA.
Preventive Cardiology Program, Columbia University Medical Center/New York-Presbyterian Hospital, New York, NY, USA.
Nutr Metab Cardiovasc Dis. 2014 Jan;24(1):100-6. doi: 10.1016/j.numecd.2013.06.003. Epub 2013 Oct 5.
Increased trans fat intake has been associated with an increased risk of cardiovascular disease (CVD). While the effect of trans fat on traditional lipids is known, it's association with LDL particle number (LDL-P), a novel marker of CVD risk, has not been established. The purpose of this study was to determine the association between trans fat intake and LDL-P over 1-year among individuals participating in a lifestyle intervention trial.
Family members (N = 400, 33% male, mean age 48 ± 13) of patients hospitalized with CVD who participated in a 1-year randomized controlled primary prevention lifestyle intervention trial and had complete dietary data and LDL-P measures at baseline and 1-year. Change in trans fat as a percentage of total diet and mean absolute change in LDL-P at 1-year was assessed using multivariate adjusted linear regression models. At baseline, there was a significant positive correlation between dietary trans fat intake and LDL-P (Beta = 37, p = 0.04). For every 1 percent change in trans fat intake there was a 27 nmol/L change in LDL-P (Beta = 27, p = 0.04) over 1-year which was independent of baseline predictors and confounders (age, sex, smoking, statin use, waist size and physical activity; Beta = 30, p = 0.03).
A reduction in trans fat intake over 1-year was significantly associated with a reduction in LDL-P independent of potential confounders. Healthcare providers should reinforce the beneficial impact of a healthy diet, and in particular modifications in trans fat intake on improving lipid profiles.
摄入反式脂肪会增加心血管疾病（CVD）的风险。虽然人们已经了解反式脂肪对传统脂质的影响，但它与 LDL 颗粒数（LDL-P）的关系，即 CVD 风险的一个新标志物，尚未得到证实。本研究旨在确定在接受生活方式干预试验的个体中，反式脂肪摄入与 LDL-P 在 1 年内的变化之间的关系。
参与为期 1 年的随机对照一级预防生活方式干预试验的 CVD 住院患者的家属（N = 400，33%为男性，平均年龄 48 ± 13 岁），并在基线和 1 年内完成了完整的饮食数据和 LDL-P 测量。使用多元调整线性回归模型评估了饮食中反式脂肪百分比的变化和 1 年内 LDL-P 的平均绝对变化。在基线时，饮食中反式脂肪的摄入与 LDL-P 呈显著正相关（Beta = 37，p = 0.04）。反式脂肪摄入量每增加 1%，LDL-P 就会变化 27 nmol/L（Beta = 27，p = 0.04），这一变化独立于基线预测因素和混杂因素（年龄、性别、吸烟、他汀类药物使用、腰围和体力活动；Beta = 30，p = 0.03）。
在 1 年内减少反式脂肪的摄入与 LDL-P 的减少显著相关，独立于潜在的混杂因素。医疗保健提供者应强调健康饮食的有益影响，特别是在减少反式脂肪摄入方面，以改善血脂谱。
