Sarngadharan M G, diMarzo Veronese F, Lee S, Gallo R C
Cancer Res. 1985 Sep;45(9 Suppl):4574s-4577s.
A high correlation was found among antibodies to human T-cell leukemia virus type III (HTLV-III), acquired immunodeficiency syndrome, and acquired immunodeficiency syndrome-related complex. With the Western blot technique the antigens (shown as proteins with molecular weights given in thousands) in HTLV-III lysates recognized by positive sera have been identified as p120, p66, p51, p41, p31, p24, and p17. The most common reactivity was toward p41. Lectin fractionation identified p120 and p41 as glycoproteins. Studies using mouse monoclonal antibodies to the p24 proteins of HTLV-I, -II, and -III showed that HTLV-I and -II have common epitopes in p24 molecule, but these are not the cross-reactive epitopes present on HTLV-III p24.
在人类Ⅲ型T细胞白血病病毒（HTLV-Ⅲ）抗体、获得性免疫缺陷综合征及获得性免疫缺陷综合征相关综合征之间发现高度相关性。利用蛋白质印迹技术，已确定阳性血清识别的HTLV-Ⅲ裂解物中的抗原（显示为分子量以千为单位的蛋白质）为p120、p66、p51、p41、p31、p24和p17。最常见的反应是针对p41。凝集素分级分离确定p120和p41为糖蛋白。使用针对HTLV-Ⅰ、-Ⅱ和-Ⅲ的p24蛋白的小鼠单克隆抗体进行的研究表明，HTLV-Ⅰ和-Ⅱ在p24分子中有共同表位，但这些不是HTLV-Ⅲ p24上存在的交叉反应表位。
