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人类免疫缺陷病毒中和抗体可识别包膜糖蛋白上的多个保守结构域。

Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins.

作者信息

Ho D D, Sarngadharan M G, Hirsch M S, Schooley R T, Rota T R, Kennedy R C, Chanh T C, Sato V L

出版信息

J Virol. 1987 Jun;61(6):2024-8. doi: 10.1128/JVI.61.6.2024-2028.1987.

DOI:10.1128/JVI.61.6.2024-2028.1987
PMID:2437327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254212/
Abstract

Serum neutralizing antibodies against the human immunodeficiency virus were frequently detected in infected individuals, and low or absent serum neutralizing titers correlated with poor prognosis. Multiple diverse human immunodeficiency virus isolates were found to exhibit similar susceptibility to neutralization by a panel of human seropositive sera, suggesting that neutralizing antibodies are largely directed against conserved viral domains. Furthermore, utilizing antisera raised against a library of synthetic env peptides, four regions which are important in the neutralization process have been identified within both human immunodeficiency virus envelope glycoproteins (gp41 and gp120). Three of these are in conserved domains and should be considered for inclusion in a candidate vaccine.

摘要

在受感染个体中经常检测到针对人类免疫缺陷病毒的血清中和抗体，血清中和滴度低或缺乏与预后不良相关。发现多种不同的人类免疫缺陷病毒分离株对一组人类血清阳性血清的中和作用表现出相似的敏感性，这表明中和抗体主要针对保守的病毒结构域。此外，利用针对合成env肽文库产生的抗血清，在人类免疫缺陷病毒包膜糖蛋白（gp41和gp120）中都鉴定出了在中和过程中重要的四个区域。其中三个位于保守结构域，应考虑将其纳入候选疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d34/254212/86f8164d2e82/jvirol00097-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d34/254212/86f8164d2e82/jvirol00097-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d34/254212/86f8164d2e82/jvirol00097-0270-a.jpg

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Glycosylation of immunodominant linear epitopes in the carboxy-terminal region of the caprine arthritis-encephalitis virus surface envelope enhances vaccine-induced type-specific and cross-reactive neutralizing antibody responses.山羊关节炎-脑炎病毒表面包膜羧基末端区域免疫显性线性表位的糖基化增强了疫苗诱导的型特异性和交叉反应性中和抗体反应。
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