Optical Bio-Microsystems Laboratory, Department of Mechanical and Industrial Engineering, Concordia University, Montreal, Quebec H3G 1M8, Canada.
Biomicrofluidics. 2012 Oct 9;6(4):46501. doi: 10.1063/1.4757968. eCollection 2012.
Integration of nano-materials in optical microfluidic devices facilitates the realization of miniaturized analytical systems with enhanced sensing abilities for biological and chemical substances. In this work, a novel method of integration of gold nano-islands in a silica-on-silicon-polydimethylsiloxane microfluidic device is reported. The device works based on the nano-enhanced evanescence technique achieved by interacting the evanescent tail of propagating wave with the gold nano-islands integrated on the core of the waveguide resulting in the modification of the propagating UV-visible spectrum. The biosensing ability of the device is investigated by finite-difference time-domain simulation with a simplified model of the device. The performance of the proposed device is demonstrated for the detection of recombinant growth hormone based on antibody-antigen interaction.
纳米材料在光学微流控器件中的集成，有助于实现具有增强生物和化学物质传感能力的小型化分析系统。在这项工作中，报道了一种将金纳米岛集成在硅上的二氧化硅-聚二甲基硅氧烷微流控器件中的新方法。该器件基于通过与集成在波导芯上的金纳米岛相互作用来实现的消逝波的纳米增强消逝技术，从而改变传播的紫外-可见光谱。通过对器件简化模型的有限差分时域模拟来研究该器件的生物传感能力。基于抗体-抗原相互作用，该设备的性能通过检测重组生长激素得到了验证。
